Results 211 to 220 of about 10,472,101 (345)

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Rainy-weather speed limit strategies on highways with variable longitudinal slopes. [PDF]

PLoS One
Li C, Sun G, Liu X, Sun H, Qiu S.
europepmc   +1 more source

A Multidimensional Perspective on Network Conditions in Telesurgery

Advanced Intelligent Systems, EarlyView.
A multidimensional framework systematically evaluates how combined network impairments influence telesurgical performance. By jointly analyzing latency, jitter, bandwidth, and packet loss, the proposed methodology identifies relevant network condition parameters and their interactions, supporting the design of reliable and safe telesurgical systems ...
Florian Heemeyer, Marco Cina, Ege Cem Kirci, Laurent Vanbever, Quentin Boehler   +4 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

TRAFFICGEN: a multi-agent LLM orchestration for smart mobility and emergency corridor pre-emption. [PDF]

Front Artif Intell
Soni G, Khekare G, Kumar Y, Rupaak S.
europepmc   +1 more source

Artificial Intelligence and Access to Justice at the ‘Shop Front’: The Potential and Limitations of Meeting Legal Need Through Technology

Australian Journal of Social Issues, EarlyView.
ABSTRACT In Australia, governments fund Community Legal Centres (CLCs) as part of the legal assistance sector (LAS) to meet the ‘legal needs’ of people experiencing disadvantage who cannot afford private legal services. Persistent unmet demand for CLCs is well‐documented. As artificial intelligence (AI) is increasingly used in private legal practice to
Catherine Hastings, Art Cotterell, Farzana Bruce   +2 more
wiley   +1 more source

A Graph Partitioning Algorithm for Parallel Agent-Based Road Traffic Simulation

SIGSIM Principles of Advanced Discrete Simulation, 2017
Yadong Xu, Wen-Tong Cai, D. Eckhoff, Suraj Nair, A. Knoll   +4 more
semanticscholar   +1 more source

PriorAug: Reliability-Aware Traffic Scenario Initialization Under Sensor-Perceived Structural and Interaction Priors. [PDF]

Sensors (Basel)
Yang K, Qu S.
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Comparative environmental evaluation of highway speed limit strategies: a microsimulation study. [PDF]

Sci Rep
Shahdah UE, Elharoun M, Ali EK, Elagamy SR.   +3 more
europepmc   +1 more source