Results 111 to 120 of about 810,781 (333)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

Phagolysosomal Trafficking Assay [PDF]

open access: yesBIO-PROTOCOL, 2014
Phagolysosomal trafficking is an important innate defense pathway that clears microbes by delivering them to lysosomes, the degradative compartment of the cell. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, subverts this host defense mechanism by arresting maturation of the phagosome.
openaire   +3 more sources

Effects of Kcne Subunit Deletion on Polarized Trafficking of the KCNQ1 Potassium Channel in Vivo [PDF]

open access: bronze, 2010
Geoffrey W. Abbott   +5 more
openalex   +1 more source

Human Trafficking in Europe: An Economic Perspective [PDF]

open access: yes, 2004
Based on a document originally prepared for the Eleventh Economic Forum of the Organization for Economic Security and Cooperation in Europe, held in Prague between 20-23 May 2003.
InFocus Programme on Promoting the Declaration on Fundamental Principles and Rights at Work   +1 more
core   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

open access: yesAdvanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu   +8 more
wiley   +1 more source

Reframing Human Trafficking: From a Criminal Justice Problem to a Social Justice Issue [PDF]

open access: yes, 2018
Laws addressing human trafficking have been passed in all 50 U.S. states as well as at the federal level. Although laws serve an important function in establishing social norms against a behavior, they can also create a belief that it is the ...
Pfeffer, Rebecca
core   +1 more source

Phase Change Material‐Driven Tunable Metasurface for Adaptive Terahertz Sensing and Communication in 6G Perceptive Networks

open access: yesAdvanced Functional Materials, EarlyView.
This study explores the benefits of metasurfaces made from functional materials, highlighting their ability to be adapted and improved for various high‐frequency applications, including communications and sensing. It first demonstrates the potential of these functional material‐based metasurfaces to advance the field of sub‐THz perceptive networks ...
Yat‐Sing To   +5 more
wiley   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

open access: yesAdvanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang   +9 more
wiley   +1 more source

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