Results 131 to 140 of about 904,971 (330)
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
Journal of Cell Biology, 2017 The primary cilium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understood.
H. Badgandi +4 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
A Global Crime Against Women: Sex Trafficking and Its Consequences [PDF]
, 2018 Sex trafficking, a form of gender-based violence in which a specific gender is the target of violence due to the imbalance of power, is a common present-day global crime (Murturi 2006:83). Women are most often victims of this specific crime, (Muturi 2006:
Ferreira, Breezy
core +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
The U.S. Response to Human Trafficking: An Unbalanced Approach [PDF]
, 2007 The United States' anti-trafficking efforts formally began with the passage of the Trafficking Victims Protection Act (TVPA) of 2000. Since then, the U.S.
Kelly Hienrich, Michelle Brane
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A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
The Game as Structure: Exploring Gendered Identities, Interactions and Macrostructures in the System of Sex Trafficking [PDF]
, 2015 Human trafficking, or trafficking in persons (TIP), is a crime where people profit from the exploitation of others through some form of labor (Polaris, 2015).
Henson, Katelyn
core +1 more source
Innovating Aircraft Repair Processes: The Role of Digitalization in Sustainability
Advanced Engineering Materials, EarlyView.This research explores how digitalization—by storing detailed non‐destructive testing data in structured DICONDE databases and creating a standard data model of the component—innovates aviation maintenance and repair processes. Coupled with a developed state‐based simulation model, it enables data‐driven, sustainable repair strategies that reduce waste,
Johanna Aigner +3 more
wiley +1 more source
Trafficking in Persons and Human Development: Towards A More Integrated Policy Response [PDF]
Poverty is often regarded as the "root cause" of trafficking, but the linkages between poverty, lack of development and trafficking are complex. For example, there is some evidence to suggest that victims of cross-border trafficking are more likely to ...
Frank Laczko, Gergana Danailova-Trainor
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