Results 271 to 280 of about 904,971 (330)

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Unlocking the black box: multimodal imaging and quantitative analysis of plant vesicular trafficking. [PDF]

Adv Biotechnol (Singap)
Zhang Y, Xu C, Zuo X, Qian H, Zhang X, Lin J, Cui Y.   +6 more
europepmc   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Glycosylation as a dynamic regulator of RLR and cGAS-STING innate immune signalling pathways. [PDF]

Commun Biol
Tong J, Zhang W, Xue M, Zheng C.
europepmc   +1 more source

Brain-Derived Neurotrophic Factor Trafficking via the Regulated Secretory Pathway: Mechanisms and Disease Implications. [PDF]

Mol Neurobiol
Ewell SN.
europepmc   +1 more source

A Multisystem Perspective of Pediatric Cell Trafficking Disorders: Within the Cells, Beneath the Signs. [PDF]

JIMD Rep
Yoldaş Çelik M, Köşeci B, Burgaç E, Yararbaş K, Çelik T, Sarıgeçili E, Koç Uçar H.   +6 more
europepmc   +1 more source

SEC3A acts as an effector of RabE1b to regulate auxin transport in arabidopsis. [PDF]

PLoS One
Qiao L, Chu J, Wang N, Tan X, Liu F, Bao Y.   +5 more
europepmc   +1 more source

Ciliary Defects in Inherited Retinal Diseases. [PDF]

Adv Genet (Hoboken)
Guo G, Li L, Zhou J, Ran J.
europepmc   +1 more source

Adverse childhood experiences, re-trafficking vulnerability, and mental health outcomes among women survivors of human trafficking in Kampala, Uganda: A cross-sectional analysis. [PDF]

PLoS One
Nkwanzi V, Bulamba RM, Okech D, Carlson C, Kyasanku E, Namakula S, Evans D, Daama A, Mugamba S, Akello D, Menya E, Nammanda JB, Nkale J, Kasirye R, Nalugoda F, Kigozi G, Nakigozi G.   +16 more
europepmc   +1 more source