Results 151 to 160 of about 490 (208)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

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Trafficking in persons in Australia: myths and realities

Global Crime, 2009
In Australia, despite greater public awareness and acknowledgement of the problem by government agencies, trafficking in persons remains a phenomenon poorly understood and researched. The true extent of Australia's human trafficking problem is not fully known, largely due to the clandestine nature of this phenomenon.
Andreas Schloenhardt
exaly   +11 more sources

Trafficking in persons report

Trends in Organized Crime, 2006
The Department of State is required by law to submit a Report each year to the U.S. Congress on foreign governments' efforts to eliminate severe forms of trafficking in persons. This Report is the sixth annual TIP Report. It is intended to raise global awareness, to highlight the growing efforts of the international community to combat human ...
exaly   +2 more sources

Trafficking in Persons

2014
This briefly reviews the literature on common perinatal mental disorders (CPMD) and describes the activities of the Perinatal Mental Health Project (PMHP) based at the University of Cape Town (UCT), South Africa. It summarizes the key lessons learnt over the 10 years regarding the integration of maternal mental health care within primary care settings.
Atsuro Tsutsumi, Takashi Izutsu
  +4 more sources

Trafficking in Persons and Victim Health in Australia

SSRN Electronic Journal, 2012
This article explores the health problems experienced by victims of trafficking in persons in Australia and analyses the domestic support schemes established to assist these victims. It focuses specifically on the health of adult, female victims who constitute the majority of identified victims, and who are the principal recipients of government ...
Schloenhardt, Andreas, Klug, Benjamin
openaire   +5 more sources

Introduction: Trafficking in Persons

Journal of Intercultural Studies, 2014
In the last 20 years, human trafficking has become a global problem of unforeseen proportions. Human trafficking affects every country in the world, regardless of socioeconomic status, history, or ...
Natividad Gutiérrez Chong, Jenny Bryson Clark   +1 more
openaire   +1 more source

Trafficking in persons

2017
Historically, protection and assistance to victims of human trafficking in many countries is anchored in migration law and dependent on whether or not a residence permit is granted to the victim. Apart from some limited exceptions, cooperation with law enforcement authorities in criminal investigations is a condition for the granting of a residence ...
openaire   +3 more sources