Results 191 to 200 of about 126,381 (308)

Integrated Health, Social, and Legal Approaches to Supporting Migrant Women Victims of Human Trafficking and Sexual Violence. [PDF]

Healthcare (Basel)
Jiménez-Lasserrotte MDM, El Marbouhe El Faqyr K, Escot MKEA, Rodas Vanegas MJ, Granero-Molina J, Hernández-Padilla JM.   +5 more
europepmc   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Punishing trafficking in persons: International standards and Australian experiences [PDF]

Bond Law Review
Matthew Cameron, Andreas Schloenhardt
doaj  

Effects of a Cluster Randomized Educational Intervention on Knowledge and Attitudes Toward Women's Trafficking Among Undergraduate Nursing Students. [PDF]

Nurs Rep
Ramírez-Zambrana C, Leon-Larios F, Ruiz-Ferron C, Casado-Mejía R.   +3 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Sex Trafficking Prevention for Youth With Disabilities: Network Analysis of Organizational Coordination. [PDF]

Res Soc Work Pract
Jenkins MR, Rizo CF, Ansong D, Hume K, Dababnah S.   +4 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

The Genotypic and Phenotypic Spectrum of GOSR2 Mutations: Clinical and Pathophysiological Insights. [PDF]

J Inherit Metab Dis
Polet SS, Siegal EZ, Fuchs SA, Tijssen MAJ, de Koning TJ.   +4 more
europepmc   +1 more source

β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, EarlyView.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

Trauma, Emotional Neglect, and Developmental Vulnerability in Children: Evidence from Albania. [PDF]

Behav Sci (Basel)
Sulstarova A, Bodinaku B, Zahaj S, Sula G, Hysi G.   +4 more
europepmc   +1 more source