Results 161 to 170 of about 599,042 (350)

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Setkání svobodných duchů. Friedrich Nietzsche a Blaise Pascal

Filosofický časopis
The text presented here is dedicated to the specific features of Pascal’s thought that Nietzsche pursued in his middle period – especially in the works Human, All Too Human and Dawn of Day.
Soška, Bernard
doaj   +1 more source

Ambivalent about Tragedy: David Blight on Bruce Catton

, 2013
November 19, 2013, marked a momentous day in the small Pennsylvania town of Gettysburg – the 150th anniversary of Lincoln’s Gettysburg Address. The 272 worded speech given four months after the Battle of Gettysburg assigned meaning to the intense ...
Kirk, Brianna E.
core  

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Ultrastrong TEMPO‐Oxidized Densified Bamboo via Interface Decoupling and Hierarchical Toughening

Advanced Science, EarlyView.
This study develops TEMPO‐oxidized densified bamboo that achieves ultrahigh strength and toughness by decoupling rigid hydrogen bonds into reversible van der Waals interactions. TEMPO oxidation reorganizes the cellulose hydrogen‐bonding network, facilitating energy dissipation via reversible interactions, thereby establishing a general strategy to ...
Ziyu Ba, Hongyun Luo, Jie Cui, Juan Guan, Zhaoliang Guo, Robert O. Ritchie   +5 more
wiley   +1 more source

Development of a multicomponent survey of experiences of tragedy-based and fear-based trauma in COVID-19 healthcare professionals. [PDF]

Front Psychol
Gilbert P, Matos M, Basran J, Morter K, Plowright P, Ferreira A, do Céu Salvador M, Kirby W.   +7 more
europepmc   +1 more source

The Tragedy of the Commons in a Fishery when Relative Performance Matters [PDF]

This paper presents a simple model of a common access fishery where fishermen care about relative performance as well as absolute profits. Our specification captures the idea that status (which depends on relative performance) in a community infuences a ...
Ngo Van Long, Stephanie F. McWhinnie
core  

Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials

Advanced Science, EarlyView.
Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan, Hengheng Zhao, Haotian Wang, Zhanjie Liu, Qian Li, Weifeng Zhang, Qingsong Zhao, Liqun Zhang, Jun Liu   +8 more
wiley   +1 more source

Distributive justice and the importance of context. [PDF]

Can Fam Physician
Ponka D.
europepmc   +1 more source

An oscillating tragedy of the commons in replicator dynamics with game-environment feedback

Proceedings of the National Academy of Sciences of the United States of America, 2016
J. Weitz, Ceyhun Eksin, Keith Paarporn, Sam P. Brown, W. Ratcliff   +4 more
semanticscholar   +1 more source