Results 61 to 70 of about 635,446 (241)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Peculiarities of the pedagogical situation at the training of bachelors on the direction 08.03.01 «Construction» on the example of discipline of specialization

Открытое образование (Москва), 2018
Requirements to the quality of students’ training are constantly growing; employers also are interested in obtaining high-quality professionals in the current system of Bachelor’s – Master’s degree. For the efficient operation of the system “lecturer” – “
Nelli I. Taraseeva
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Prospects for using an artificial intelligence model as an educational platform for training microbiologists

RUDN Journal of Informatization in Education
Problem statement. Artificial intelligence (AI) has great potential in various fields of medicine, including microbiology, but AI and educational platforms using AI are not yet sufficiently used in professional training.
Pavel N. Filippov, Andrey G. Komarov, Konstantin M. Lobastov, Rustam A. Khakimov, Vasiliy V. Shevtsov, Natalia A. Usova   +5 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

DIGITAL PERSONAL MENTORING AGREEMENT AS A TOOL FOR REGULATING INTERNET BLOGGERS’ EDUCATIONAL ACTIVITIES

Правовое государство: теория и практика
The current Internet environment is almost unimaginable without bloggers – active social media participants who share content focused on particular topics on their pages, engaging a target audience (subscribers) to view and assess it.
KOLESNICHENKO Olga Viktorovna
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Examining the multi-faceted relationship between sight translation and simultaneous interpreting

Translation and Interpreting : the International Journal of Translation and Interpreting Research
The study investigated threeaspects of the relationship between sight translation (ST) and simultaneous interpreting (SI): 1) predictive power of traineeinterpreters’ ST performance for their SI performance, 2) comparison between trainees ...
Yue Li
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The teaching swimming for understanding framework: an integrated approach to aquatic education for children and instructors

Frontiers in Sports and Active Living
This study evaluates the impact of the Teaching Swimming for Understanding (TSfU) program within a comprehensive aquatic education framework that integrates motor, cognitive, emotional, and social learning, extending beyond sports success. A total of 200
Gabriele Signorini, Raffaele Scurati, Roberto Del Bianco, Pietro Luigi Invernizzi, Marta Rigon   +4 more
doaj   +1 more source