Results 101 to 110 of about 1,096,384 (305)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Monitoring training load: necessity, methods and applications [PDF]
, 2018 Regular physical activity and participation in organized sports is important contributor to performance and for overall health and fitness in humans of various age range.
Mäestu, Jarek, Pind, Rasmus
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Training load monitoring by position and task in professional men´s basketball
E-balonmano.com: Revista de Ciencias del Deporte, 2021 The aim of this study was to analyze the training load of the different tasks of a professional basketball team, based on the tasks and player positions. A total of 10 professional basketball players participated (Mage = 23.70; SD = 2.26) who carried out
José Carlos Ponce Bordón +3 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Can clinicians and scientists explain and prevent unexplained underperformance syndrome in elite athletes: an interdisciplinary perspective and 2016 update [PDF]
, 2015 The coach and interdisciplinary sports science and medicine team strive to continually progress the athlete's performance year on year. In structuring training programmes, coaches and scientists plan distinct periods of progressive overload coupled with ...
Collins, D. +3 more
core +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
An overview and comparative analysis of Recurrent Neural Networks for Short Term Load Forecasting
, 2017 The key component in forecasting demand and consumption of resources in a supply network is an accurate prediction of real-valued time series. Indeed, both service interruptions and resource waste can be reduced with the implementation of an effective ...
Bianchi, Filippo Maria +4 more
core +1 more source
Dose-Response Relationship between Training Load and Changes in Aerobic Fitness in Professional Youth Soccer Players [PDF]
, 2018 Purpose: The aim of this study was to compare the dose-response relationship between, traditional arbitrary speed thresholds versus an individualised approach, with changes in aerobic fitness in professional youth soccer players.
Fitzpatrick, John +2 more
core +1 more source