Results 41 to 50 of about 265,383 (315)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

A New Approach to Quantify Soccer Players’ Readiness through Machine Learning Techniques

Applied Sciences, 2023
Previous studies have shown that variation in PlayerLoad (PL) could be used to detect fatigue in soccer players. Machine learning techniques (ML) were used to develop a new locomotor efficiency index (LEI) based on the prediction of PL.
Mauro Mandorino, Antonio Tessitore, Cédric Leduc, Valerio Persichetti, Manuel Morabito, Mathieu Lacome   +5 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

COVID-19 Surveillance and Competition in Sport: Utilizing Sport Science to Protect Athletes and Staff during and after the Pandemic

Journal of Functional Morphology and Kinesiology, 2020
The ongoing Coronavirus 2 (COVID-19) pandemic abruptly halted athletic competition and standard training practices, consequently generating great confusion surrounding when and how to safely reintroduce sports.
Joshua Hagen, Jason D. Stone, W. Guy Hornsby, Mark Stephenson, Robert Mangine, Michael Joseph, Scott Galster   +6 more
doaj   +1 more source

Monitoring training loads: from training to competition

Pedagogics, psychology, medical-biological problems of physical training and sports, 2019
Aims: Monitoring is a new method that allows coaches and physical trainers to manage training in order to meet the needs of athletes. This study aims to evaluate through a scientific approach the homogeneity between the training program established by the coach in the pre-competition period, and the characteristics of the competition.
N. Tanda, N. Bougrine, A. Arfaoui, H. Moufti, L. Zeghari   +4 more
openaire   +3 more sources

Debunking the myths about training load, injury and performance: empirical evidence, hot topics and recommendations for practitioners

, 2020
Background: Since 2000, there has been a rapid growth in training load and injury research. In the past 5 years alone, a total of 38 studies (from as many as 24 different research groups, and 11 different sports) have investigated the relationship ...
Gabbett, Tim J.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Session Rating of Perceived Exertion Is a Valid Method to Monitor Intensity of Exercise in Adults with Acute Burn Injuries

European Burn Journal
Measuring exercise intensity for safety and to inform prescription in acute burn survivors, is challenging. This study aimed to assess the validity of adult patient end-of-workout rating of session perceived exertion (sRPE); and calculated training load (
Joanne S. Page, Dale W. Edgar, Tiffany L. Grisbrook, Angela Jacques, Paul M. Gittings, Fiona M. Wood, Carly J. Brade   +6 more
doaj   +1 more source

Developmental Training Model for the Sport Specialized Youth Athlete: A Dynamic Strategy for Individualizing Load-Response During Maturation

, 2021
CONTEXT: Most available data on athletic development training models focus on adult or professional athletes, where increasing workload capacity and performance is a primary goal.
Saffel, Heather, Hartwig, Tim, Gabbett, Tim J., Jayanthi, Neeru, Cumming, Sean P., Schley, Stacey, Myer, Gregory D.   +6 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source