Results 71 to 80 of about 265,383 (315)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Does the energy expenditure associated with training influence reduced adiposity in practitioners of exercise? Data from a cross-sectional population study

Anais da Academia Brasileira de Ciências
Meta-analyses have shown modest weight loss with physical training. Low training load can be one possible cause, however this has not yet been investigated.
RAQUEL SUELEN B. DA SILVA, MARIZÂNGELA F. DE SOUZA, MATHEUS DA S. COSTA, JOANE RAQUEL E. BATISTA, GISELE AUGUSTA M. FRANCA, FRANCISCA KARINNY L. BARBOSA, CAROLINA F.A. LOPES, GLÊBIA A. CARDOSO, ALEXANDRE S. SILVA   +8 more
doaj   +1 more source

Training Load, Immune Status, and Clinical Outcomes in Young Athletes: A Controlled, Prospective, Longitudinal Study

Frontiers in Physiology, 2018
Introduction: Beside positive effects on athlete's health, competitive sport can be linked with an increased risk of illness and injury. Because of high relative increases in training, additional physical and psychological strains, and an earlier ...
Katharina Blume, Nina Körber, Dieter Hoffmann, Bernd Wolfarth   +3 more
doaj   +1 more source

Acute effects of training load on contractile properties during a competitive microcycle in elite soccer players

, 2020
The aim of this study was to examine changes in muscle contractile properties across a microcycle of training in professional soccer players during the in-season period. Nineteen professional soccer players were assessed with tensiomyography (TMG) on the
Francisco Corredoira, Alexandra Pérez-Ferreirós, Ezequiel Rey, María Fernández-Villarino, Pablo B. Costa   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Greater Neural Adaptations following High- vs. Low-Load Resistance Training

Frontiers in Physiology, 2017
We examined the neuromuscular adaptations following 3 and 6 weeks of 80 vs. 30% one repetition maximum (1RM) resistance training to failure in the leg extensors.
Nathaniel D. M. Jenkins, Nathaniel D. M. Jenkins, Amelia A. Miramonti, Ethan C. Hill, Cory M. Smith, Kristen C. Cochrane-Snyman, Terry J. Housh, Joel T. Cramer   +7 more
doaj   +1 more source

Generation of synthetic benchmark electrical load profiles using publicly available load and weather data

, 2014
Electrical load profiles of a particular region are usually required in order to study the performance of renewable energy technologies and the impact of different operational strategies on the power grid. Load profiles are generally constructed based on
Pillai, Gobind, Putrus, Ghanim, Pearsall, Nicola, Gopalakrishna Pillai, Gobind   +3 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Optimizing Team Sport Training With Multi-Objective Evolutionary Computation

International Journal of Computer Science in Sport, 2021
This research introduces a new novel method for mathematically optimizing team sport training models to enhance two measures of athletic performance using an evolutionary computation based approach.
Connor Mark, Faganan David, Watters Barry, McCaffery Fergal, O’Neill Michael   +4 more
doaj   +1 more source

Subjective skeletal discomfort measured using a comfort questionnaire following a load carriage exercise [PDF]

, 2009
Objective: Limited research has been conducted into the effect of load carriage on discomfort and injuries. This study aimed to determine the skeletal discomfort for part-time soldiers who completed a 1-hour field march carrying 24 kg.
Haslam, Roger, Birrell, Stewart A.
core