Results 51 to 60 of about 5,607,953 (307)

Evaluating health visitors’ existing knowledge of Down syndrome and the effect of a training workshop [PDF]

open access: yes, 2019
© 2018 The Authors. Journal of Policy and Practice in Intellectual Disabilities published by International Association for the Scientific Study of Intellectual and Developmental Disabilities and Wiley Periodicals, Inc.Children with Down syndrome are at ...
Mengoni, Silvana, Redman, Sandra
core   +2 more sources

Identification of chemical and explosive goods whiletransferring through customs border: global threats and challenges for countries

open access: yesCхід, 2017
The article substantiates the dangers of illegal chemical and explosive goods transferring between countries. The threats arising from the use of chemical precursors for the production of homemade explosive weapons, including terrorist organizations ...
Andriy Voyotseshchyk
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

E-consulting of Small and Medium Agribusiness Enterprises: The case of eEurope Godigital application into the Peloponnese Region [PDF]

open access: yes, 2002
This study describes the design and development of a web-based electronic training system aiming at business operations of small and medium-sized agribusiness enterprises (SMAEs). The proposed system will meet current and future needs of SMAEs for timely,
Costopoulou, C. I.   +2 more
core  

The Gates Malaria Partnership: a consortium approach to malaria research and capacity development.

open access: yes, 2012
Recently, there has been a major increase in financial support for malaria control. Most of these funds have, appropriately, been spent on the tools needed for effective prevention and treatment of malaria such as insecticide-treated bed nets, indoor ...
Bhasin, Amit   +2 more
core   +1 more source

Training verbal working memory in children with mild intellectual disabilities: effects on problem-solving [PDF]

open access: yes, 2018
This multiple case study explores the effects of a cognitive training program in children with mild to borderline intellectual disability. Experimental training effects were evaluated comparing pre-post-test changes after (a) a baseline phase versus a ...
Caira, Simona   +6 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Investigating the influence of music training on verbal memory [PDF]

open access: yes, 2017
Previous research has shown that musical training is associated with enhanced verbal memory. The current study investigated the generality of this association by presenting undergraduates who had received musical training (n = 20) and undergraduates with
Dewhurst, Stephen A.   +1 more
core   +1 more source

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