Results 81 to 90 of about 5,569,149 (288)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Recollected in tranquility : FE teachers’ perceptions of their initial teacher training [PDF]

, 2003
"The main research question posed by the project was: ‘What are FE teachers’ perceptions of the effectiveness of initial training in helping them to teach and to support learning?’" -- page ...
Clow, Ros, Harkin, Joe, Hillier, Yvonne
core  

Training telescope operators and support astronomers at Paranal

, 2016
The operations model of the Paranal Observatory relies on the work of efficient staff to carry out all the daytime and nighttime tasks. This is highly dependent on adequate training.
Anderson, Joe, Benn, Chris R., Boffin, Henri M.J., de Wit, Willem-Jan, Gadotti, Dimitri A., Girard, Julien H.V., Peck, Alison B., Pino, Andres, Seaman, Robert L.   +8 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

El papel de la institución en el escoger, acoger y acompañar al profesor universitario O papel da instituição para escolher, acolher e acompanhar ao professor universitário The role of the institution in choosing, receiving and chaperone professors in the university

Investigación y Educación en Enfermería, 2011
Objetivo. Analizar el papel de la institución en el proceso de escoger, acoger y acompañar al profesor universitario. Metodología. Estudio cualitativo cuyo cuerpo de análisis estuvo compuesto por 32 participaciones en un foro temático de un grupo de ...
Maria de Lourdes da Silva Marques Ferreira
doaj  

Enhancing personal development of learners with disabilities through pedagogical practices: Teachers’ perspectives in the High Glen district, Zimbabwe

International Journal of Studies in Inclusive Education
One of the most critical tasks of special and inclusive education in the current context of education system reform is the social and pedagogical support of children with disabilities to enhance personal development.
Loveness Dube, Liana Musekiwa, James Maizere   +2 more
doaj   +1 more source

Basic life support training [PDF]

Anaesthesia, 1992
G R, Lauder, P J, McQuillan, J W, Sear
openaire   +2 more sources

Working in partnership through early support: distance learning text: working with parents in partnership (book chapter) [PDF]

, 2007
This is a chapter from the distance learning text for the 'Working in Partnership through Early Support' accredited training programme. "Our intention in this chapter... is to provide a theory of helping, known as the Family Partnership Model.
Davis, Hilton, Meltzer, Lorraine
core