Results 221 to 230 of about 2,767,935 (333)

The Relationship of Fish Functional Traits, Physicochemical Characteristics and Exotic Fish (Micropterus salmoides and Lepomis macrochirus) [PDF]

Misheel Bold, Kyujin Kim, Jung Hoon Yoon, Mooseong Kim, Ju‐Duk Yoon, Jae-Goo Kim, Keonhee Kim, Min‐Ho Jang   +7 more
openalex   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

commecometrics: an R package for trait-environment modelling at the community level. [PDF]

Biodivers Data J
Hurtado-Materon MA, Siciliano-Martina L, Short RA, McGuire JL, Lawing AM.   +4 more
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Root mixing effects on belowground decomposition depend on mycorrhizal type. [PDF]

Nat Commun
Jiang L, Hättenschwiler S, Ma N, Zheng J, Shi W, Ying Y, Li S, Yan H, Kou L.   +8 more
europepmc   +1 more source

Bagasse Yield and Quality Traits of Silage Made From Juice-Extracted Sweet Sorghum

, 2023
Celal Yücel, Feyza Bilgin, İlker İnal
openalex   +2 more sources

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

Early socioeconomic conditions to children's trait resilience: longitudinal mediation effects of mothers' and fathers' parenting. [PDF]

Child Adolesc Psychiatry Ment Health
Yu M, Tng GYQ, Lin Z, Chen H, Eriksson JG, Chong YS, Tiemeier H, Setoh P.   +7 more
europepmc   +1 more source

QTL-seq: rapid mapping of quantitative trait loci in rice by whole genome resequencing of DNA from two bulked populations.

The Plant Journal, 2013
H. Takagi, A. Abe, Kentaroh Yoshida, S. Kosugi, S. Natsume, Chikako Mitsuoka, Aiko Uemura, Hiroe Utsushi, Muluneh Tamiru, Shohei Takuno, H. Innan, L. Cano, S. Kamoun, R. Terauchi   +13 more
semanticscholar   +1 more source

Principal component regression of the morphostructural traits of West African dwarf sheep

, 2021
Abdulraheem Adedeji Bello-Ibiyemi, Abdulraheem Adedeji Bello-Ibiyemi, Mathew Wheto, A. S. Adenaike, John S. Decampos, D. O. Ogunlakin, M. Atunnise, S. Shola, C. O. N. Ikeobi   +8 more
openalex   +2 more sources