Results 81 to 90 of about 2,767,935 (333)

Local genetic sex differences in quantitative traits

Nature Communications
Many traits show small global sex differences in genetic correlations and heritability. However, how these differences are distributed across the genome remains unknown. Here, we use LAVA to test for local genetic sex differences in genetic correlations,
Emil Uffelmann, Christiaan de Leeuw, Marijn Schipper, Danielle Posthuma   +3 more
doaj   +1 more source

On the convergence of the maximum likelihood estimator for the transition rate under a 2-state symmetric model

, 2019
Maximum likelihood estimators are used extensively to estimate unknown parameters of stochastic trait evolution models on phylogenetic trees. Although the MLE has been proven to converge to the true value in the independent-sample case, we cannot appeal ...
Dinh, Vu, Ho, Lam Si Tung, Matsen IV, Frederick A., Suchard, Marc A.   +3 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pitfalls and Remedies for Cross Validation with Multi-trait Genomic Prediction Methods. [PDF]

, 2019
Incorporating measurements on correlated traits into genomic prediction models can increase prediction accuracy and selection gain. However, multi-trait genomic prediction models are complex and prone to overfitting which may result in a loss of ...
Cheng, Hao, Runcie, Daniel
core   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Addressing neuroticism in psychological treatment [PDF]

, 2017
Neuroticism has long been associated with psychopathology and there is increasing evidence that this trait represents a shared vulnerability responsible for the development and maintenance of a range of common mental disorders. Given that neuroticism may
Barlow, David H., Sauer-Zavala, Shannon, Wilner, Julianne G.   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Exploration of the pearl millet phospholipase gene family to identify potential candidates for grain quality traits

BMC Genomics
Background Phospholipases constitute a diverse category of enzymes responsible for the breakdown of phospholipids. Their involvement in signal transduction with a pivotal role in plant development and stress responses is well documented.
Mazahar Moin, Pradeep Reddy Bommineni, Wricha Tyagi   +2 more
doaj   +1 more source

The curvilinear relationship between work pressure and momentary task performance: The role of state and trait Core Self-Evaluations

Frontiers in Psychology, 2015
Whereas several studies have demonstrated that Core Self-Evaluations (CSE)–or one’s appraisals about one’s own self-worth, capabilities, and competences–relate to job outcomes, less is known about the mechanisms underlying these relationships.
Joeri eHofmans, Jonas eDebusscher, Edina eDóci, Andromachi eSpanouli, Filip eDe Fruyt   +4 more
doaj   +1 more source

A simple mathematical model of gradual Darwinian evolution: Emergence of a Gaussian trait distribution in adaptation along a fitness gradient [PDF]

, 2013
We consider a simple mathematical model of gradual Darwinian evolution in continuous time and continuous trait space, due to intraspecific competition for common resource in an asexually reproducing population in constant environment, while far from ...
A Calsina, A Sasaki, EV Koonin, GP Karev, GR Price, I Gudelj, JAJ Metz, KM Page, LH Liow, M Kimura, M Turelli, N Champagnat, NH Barton, O Hallatschek, P Schuster, PD Taylor, R Dawkins, R Lande, RA Fisher, RG Bowers, SAH Geritz, U Dieckmann, Vadim N. Biktashev   +22 more
core   +4 more sources