Results 41 to 50 of about 25,488 (234)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Evaluation and telemetry-based detection of GPS spoofing effects on UAV navigation using software-defined radio

Scientific Reports
This paper presents an experimental investigation into the vulnerabilities of autonomous drone navigation systems under GPS spoofing attacks using Software Defined Radio (SDR).
Raj Hakani, Abhishek Rawat, Manan Shah, Pavan Verma   +3 more
doaj   +1 more source

BAARTR: Boundary-Aware Adaptive Regression for Kinematically Consistent Vessel Trajectory Reconstruction from Sparse AIS

Journal of Marine Science and Engineering
The Automatic Identification System (AIS) frequently suffers from data loss and irregular report intervals in real maritime environments, compromising the reliability of downstream navigation, monitoring, and trajectory reconstruction tasks.
Hee-jong Choi, Joo-sung Kim, Dae-han Lee
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Concept of an AI-Based System for Adaptively Landing UAVs on a Mobile Platform by Relying on Sensor Fusion and RNN

Problems of Mechatronics Armament Aviation Safety Engineering
The purpose of this article is to propose and verify the concept of an autonomous control system capable of precisely manoeuvring and safely landing unmanned aerial vehicles on a mobile platform under highly variable environmental conditions.
Kasjan PAWELEC (kasjan.pawelec@student.wat.edu.pl), Wacław WOSZCZYK (waclaw.woszczyk@student.wat.edu.pl), Maciej PAJUNK (maciej.pajunk@student.wat.edu.pl), Tomasz PACANA (tomasz.pacana@student.wat.edu.pl), Norbert SUPEŁO (norbert.supelo@student.wat.edu.pl), Natalia DANIEL (natalia.daniel@wat.edu.pl)   +5 more
semanticscholar   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Attention-Based Multimodal Framework for Athlete-Performance Analysis and Rehabilitation Monitoring Using Vision and Wearable Sensors

Bioengineering
Background: Advances in monitoring systems featuring wearable sensors, computer vision, and artificial intelligence (AI) have been increasingly used in sports science and rehabilitation practices as a means of movement pattern analysis, injury prevention,
Mohammed Alonazi, Iqra Aijaz Abro, Maha Abdelhaq, Raed Alsaqour, Ahmad Jalal, Hui Liu   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source