Results 61 to 70 of about 87,604 (282)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Trajectory Privacy Protection Scheme Based on the Replacement of Stay Points
Applied SciencesLocation-based services generate a large amount of location and trajectory data, which contain rich spatiotemporal and semantic information. Publishing these data without proper protection can seriously threaten users’ trajectory privacy.
Wanqing Wu, Delong Li
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Adaptive-parameter memetic algorithm for privacy-preserving trajectory data publishing: A multi-objective optimization approach [PDF]
Trajectory data has grown pervasive, benefiting practical applications, including transportation administration and location-based operations. Nevertheless, trajectories may reveal extremely sensitive information about an individual, including movement ...
Jahan, Samsad +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
THBase: A Coprocessor-Based Scheme for Big Trajectory Data Management
, 2019 The rapid development of distributed technology has made it possible to store and query massive trajectory data. As a result, a variety of schemes for big trajectory data management have been proposed.
Jinghua Niu, Liangli Ma, Jiwei Qin
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Design and Development of a Ship Trajectory Data Management and Analysis System Based on AIS
, 2021 To address the data storage, management, analysis, and mining of ship targets, the object-oriented method was employed to design the overall structure and functional modules of a ship trajectory data management and analysis system (STDMAS).
Yasong Luo +3 more
core +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source