Results 61 to 70 of about 33,087,881 (268)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Algorithms for trajectory integration in multiple views [PDF]

open access: yes, 2009
PhDThis thesis addresses the problem of deriving a coherent and accurate localization of moving objects from partial visual information when data are generated by cameras placed in di erent view angles with respect to the scene.
Kayumbi-Kabeya, Gabin-Wilfried
core   +4 more sources

E-IMPO: A Reversible and GPU-Scalable Privacy Framework for High-Dimensional Mobility Data Publishing

open access: yesIEEE Access
This paper presents E-IMPO, a scalable and reversible extension of the In-Memory Perturbation Optimizer (IMPO) for privacy-preserving mobility data publishing.
Chetneti Srisa-An   +1 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Trajectory generation for road vehicle obstacle avoidance using convex optimization [PDF]

open access: yes, 2010
This paper presents a method for trajectory generation using convex optimization to find a feasible, obstacle-free path for a road vehicle. Consideration of vehicle rotation is shown to be necessary if the trajectory is to avoid obstacles specified in a ...
H Gollee   +6 more
core   +1 more source

Trajectory optimization for the Hevelius-lunar microsatellite mission [PDF]

open access: yes, 2005
In this paper trajectory optimisation for the Hevelius mission is presented. The Hevelius-Lunar Microsatellite Mission - is a multilander mission to the dark side of the Moon, supported by a relay microsatellite, orbiting on a Halo orbit around L2. Three
Colombo, Camilla   +3 more
core   +3 more sources

A Trajectory Privacy Protection Scheme Based on the Replacement of Stay Points

open access: yesApplied Sciences
Location-based services generate a large amount of location and trajectory data, which contain rich spatiotemporal and semantic information. Publishing these data without proper protection can seriously threaten users’ trajectory privacy.
Wanqing Wu, Delong Li
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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