Results 31 to 40 of about 75,520 (209)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

CLM:differential privacy protection method for trajectory publishing

Tongxin xuebao, 2017
In order to solve the problem existing in differential privacy preserving publishing methods that the independent noise was easy to be filtered out,a differential privacy publishing method for trajectory data (CLM),was proposed.A correlated Laplace ...
Hao WANG, Zheng-quan XU, Li-zhi XIONG, Tao WANG   +3 more
doaj   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Shape similarity differential privacy trajectory protection mechanism based on relative entropy and K-means

Tongxin xuebao, 2021
To solve the problem that most studies had not fully considered the sensitivity of location to privacy budget and the influence of trajectory shape, which made the usability of published trajectory poor, a shape similarity differential privacy trajectory
Suxia ZHU, Shulun LIU, Guanglu SUN
doaj   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Dummy trajectory privacy protection scheme for trajectory publishing based on the spatiotemporal correlation

Tongxin xuebao, 2016
The spatiotemporal correlation was analyzed between neighboring locations and the trajectories similarity from the movement direction, the reachable time between neighboring locations and the movement distance, and a dummy trajectory privacy protection ...
Kai-yue LEI, Xing-hua LI, Hai LIU, Zhuo-xiong PEI, Jian-feng MA, Hui LI   +5 more
doaj   +2 more sources

Time-varying dynamic modeling and trajectory tracking control for variable-load unmanned aerial vehicle [PDF]

Frontiers of Agricultural Science and Engineering
The dynamic variation issues of variable-load unmanned aerial vehicle (UAV) used in agricultural plant protection activities was addressed by a disturbance-resistant control system based on PD (proportional-derivative) sliding mode control. First, a time-
Xin ZHANG, Shuting XU, Wenjie CHANG, Feng KANG   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source