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Pathophysiology of TRALI: current concepts
Intensive Care Medicine, 2007Transfusion-related acute lung injury (TRALI) is a life-threatening adverse event in blood transfusion and is considered the most common cause of transfusion-related fatalities in the United States and the United Kingdom. TRALI and acute respiratory distress syndrome (ARDS) share a common clinical definition except that TRALI is temporally and ...
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Transfusion, 2007
Transfusion‐related acute lung injury (TRALI) is a leading cause of transfusion‐associated morbidity and mortality. The National Heart, Lung, and Blood Institute (NHLBI) and Canadian Consensus Conference definitions of TRALI exclude cases of mild TRALI. As a result, many cases of mild TRALI are likely to be missed.
Amanda, Davis +5 more
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Transfusion‐related acute lung injury (TRALI) is a leading cause of transfusion‐associated morbidity and mortality. The National Heart, Lung, and Blood Institute (NHLBI) and Canadian Consensus Conference definitions of TRALI exclude cases of mild TRALI. As a result, many cases of mild TRALI are likely to be missed.
Amanda, Davis +5 more
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Transfusion Medicine Reviews, 2004
This article includes a retrospective review of fatalities caused by transfusion-related acute lung injury (TRALI) over a 5-year period (from 1997 to 2002) that were reported to the Center for Biologics Evaluation and Research involving 58 recipient deaths and the corresponding 63 blood component donors. Descriptive statistics are presented.
Leslie, Holness +3 more
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This article includes a retrospective review of fatalities caused by transfusion-related acute lung injury (TRALI) over a 5-year period (from 1997 to 2002) that were reported to the Center for Biologics Evaluation and Research involving 58 recipient deaths and the corresponding 63 blood component donors. Descriptive statistics are presented.
Leslie, Holness +3 more
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TRALI : aspects physiopathologiques
Réanimation, 2011Le TRALI (transfusion-related acute lung injury) est defini cliniquement comme un oedeme pulmonaire lesionnel survenant dans les six heures suivant la transfusion d’un produit sanguin. C’est une cause majeure de morbimortalite liee a la transfusion. Sa physiopathologie est complexe et n’est pas totalement comprise. Le TRALI est le resultat d’une lesion
S. Susen, J. -Y. Muller, Y. Ozier
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Blood, 2009
Abstract Abstract SCI-48 Transfusion related acute lung injury (TRALI) is clinically defined as the new onset of acute lung injury within 6 hours of a transfusion. In TRALI a transfusion activates neutrophils leading to pulmonary leukostasis, endothelial damage, capillary leak and pulmonary edema.
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Abstract Abstract SCI-48 Transfusion related acute lung injury (TRALI) is clinically defined as the new onset of acute lung injury within 6 hours of a transfusion. In TRALI a transfusion activates neutrophils leading to pulmonary leukostasis, endothelial damage, capillary leak and pulmonary edema.
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Single hospital experience of TRALI
Transfusion, 2003BACKGROUND: TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported.STUDY DESIGN AND METHODS: This study was an observational study carried out in a single hospital.RESULTS: Eleven cases of TRALI were recognized over 12 years.
Wallis JP +3 more
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Transfusion Medicine, 2005
TRALI is a life‐threatening complication from the transfusion of a blood product. It is characterised by a clinical constellation of signs and symptoms including dyspnoea, cyanosis, hypotension, tachycardia, fever, chills and bilateral non‐cardiogenic pulmonary oedema.
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TRALI is a life‐threatening complication from the transfusion of a blood product. It is characterised by a clinical constellation of signs and symptoms including dyspnoea, cyanosis, hypotension, tachycardia, fever, chills and bilateral non‐cardiogenic pulmonary oedema.
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Tracking TRALI in target populations
Blood, 2011A prospective, case-controlled study in cardiac surgery reveals a high incidence (2.4%) of TRALI despite the introduction of plasma from male donors, indicating a need for additional interventions in susceptible populations.
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