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The effect of tramadol on blood glucose concentrations: a systematic review
Expert Review of Clinical Pharmacology, 2020Introduction Studies comprehensively summarizing the impact of tramadol use on glucose homeostasis are very sparse. Thus, the present study was performed to collect and summarize the latest information about this issue in a systematic way.
S. Nakhaee +6 more
semanticscholar +1 more source
Tramadol in pregnancy and lactation
International Journal of Obstetric Anesthesia, 2012Tramadol produces analgesic effects through both non-opioid and weak opioid activity and is commonly used to treat mild to moderate pain. It has been in use for over 30 years and has a well-established safety profile in the general population. Since tramadol is not licensed for use in pregnancy and lactation, there is limited clinical research on its ...
Michael J. Paech +3 more
openaire +3 more sources
2004
Peripheral neuropathic pains often include symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the peripheral nervous system.We aimed to review systematically the evidence from randomised ...
Rudolf Martin Dühmke +2 more
openaire +4 more sources
Peripheral neuropathic pains often include symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the peripheral nervous system.We aimed to review systematically the evidence from randomised ...
Rudolf Martin Dühmke +2 more
openaire +4 more sources
Clinical Pharmacology of Tramadol
Clinical Pharmacokinetics, 2004Tramadol, a centrally acting analgesic structurally related to codeine and morphine, consists of two enantiomers, both of which contribute to analgesic activity via different mechanisms. (+)-Tramadol and the metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the mu opioid receptor.
Stefan Grond, Armin Sablotzki
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1998
A 61‐year‐old women receiving warfarin after mitral valve replacement experienced extensive ecchymoses after starting tramadol therapy. Laboratory values revealed critical elevations of prothrombin time and international normalized ratio. The patient's coagulation values returned to acceptable levels after discontinuing tramadol and temporarily ...
Jonell R. Sabbe +2 more
openaire +3 more sources
A 61‐year‐old women receiving warfarin after mitral valve replacement experienced extensive ecchymoses after starting tramadol therapy. Laboratory values revealed critical elevations of prothrombin time and international normalized ratio. The patient's coagulation values returned to acceptable levels after discontinuing tramadol and temporarily ...
Jonell R. Sabbe +2 more
openaire +3 more sources
Drugs, 1997
(+/-)-Tramadol is a synthetic 4-phenyl-piperidine analogue of codeine. It is a central analgesic with a low affinity for opioid receptors. Its selectivity for mu receptors has recently been demonstrated, and the M1 metabolite of tramadol, produced by liver O-demethylation, shows a higher affinity for opioid receptors than the parent drug.
Dayer, Pierre +2 more
openaire +3 more sources
(+/-)-Tramadol is a synthetic 4-phenyl-piperidine analogue of codeine. It is a central analgesic with a low affinity for opioid receptors. Its selectivity for mu receptors has recently been demonstrated, and the M1 metabolite of tramadol, produced by liver O-demethylation, shows a higher affinity for opioid receptors than the parent drug.
Dayer, Pierre +2 more
openaire +3 more sources
Tramadol, naloxone, and seizures
Clinical Toxicology, 2019To the Editor,We read with great interest the article by Murray, et al. titled “Seizures in Tramadol Overdoses Reported in the ToxIC Registry: Predisposing Factors and the Role of Naloxone” and wou...
Neeraj Chhabra +3 more
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Tramadol-induced hypoglycaemia
Postgraduate Medical Journal, 2017A 58-year-old Caucasian male patient attended the emergency department with hypoglycaemia (2.3 mmol/L). This was identified by paramedics following an episode of reduced responsiveness while the patient was at home with his wife. This was successfully treated with 500 mL of intravenous glucose 5%. The patient had a medical history of diabetes mellitus
Thomas Cronin, Luke Francis Smith
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Extended-release tramadol (tramadol ER) in the treatment of chronic low back pain.
Journal of Opioid Management, 2018BACKGROUND This study evaluated the safety and efficacy of tramadol ER 300 mg and 200 mg versus placebo once daily in the treatment of chronic low back pain, using an open-label run-in followed by, without washout, a randomized controlled study design.
Gary J. Vorsanger, PhD, MD +4 more
semanticscholar +1 more source
Tramadol for the treatment of fibromyalgia
Expert Review of Neurotherapeutics, 2015Tramadol is a novel, synthetic opioid receptor agonist with serotonin-norepinephrine reuptake inhibitor properties that is often prescribed acutely for painful conditions. Fibromyalgia (FM) is a chronic painful condition that is difficult to treat and until more recently has had no approved medical treatments.
Thomas L Schwartz, Ashley J B MacLean
openaire +3 more sources