Results 121 to 130 of about 7,801 (328)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Fishermen Interviews: A Cost-Effective Tool for Evaluating the Impact of Fisheries on Vulnerable Sea Turtles in Tunisia and Identifying Levers of Mitigation. [PDF]

Animals (Basel), 2023
Louhichi M, Girard A, Jribi I.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Disco Valai [PDF]

, 1985
The dico vali (disco net) is an adaptation of the triple-walled entangling net, the trammel net, which, in India, has hitherto been confined to reservoir and estuarine fisheries.
Ebenezer, I P, Joel, J J
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Campionamento biologico delle catture commerciali Sezione III.C - Variabili biologiche relative al mestiere e dei parametri biologici Sezione III.E - Variabili biologiche relative agli stock del Programma Nazionale Sub-area Geografica (GSA16) – Stretto di Sicilia Anno 2015 [PDF]

, 2016
Il campionamento biologico delle catture/sbarcati commerciali, sezione C – Relative al mestiere ed E – Relative agli stock, nell’ambito del Programma Nazionale per la Raccolta Dati Alieutici (PNRDA) (Reg. Ce.
Badalucco, C., Basilone, G., Campanella, N., Chirco, P., Colloca, F., Cusumano, S., De Luca, B., Di Maria, A., Fiorentino, F., Fontana, I., Gancitano, S., Gancitano, Vita, Garofalo, Germana, Giacalone, G., Giusto, G.B, Gristina, M., Ingrande, G., Mangano, S., Massi, D., Milazzo, A., Patti, B., Patti, C., Pulizzi, M., Ragonese, S., Rizzo, F., Rizzo, P., Sinacori, Giuseppe, Titone, Antonino   +27 more
core  

Atmospheres of Hot Super-Earths

, 2011
Hot super-Earths likely possess minimal atmospheres established through vapor saturation equilibrium with the ground. We solve the hydrodynamics of these tenuous atmospheres at the surface of Corot-7b, Kepler 10b and 55 Cnc-e, including idealized ...
Adams, Batalha, Batygin, Borucki, Fischer, Gaidos, Menou, Perna, Perna, Schaefer, Showman, Tachinami, Trammel, Winn   +13 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Assessment of Harbour Porpoise Bycatch along the Portuguese and Galician Coast: Insights from Strandings over Two Decades. [PDF]

Animals (Basel), 2023
Torres-Pereira A, Araújo H, Monteiro SS, Ferreira M, Bastos-Santos J, Sá S, Nicolau L, Marçalo A, Marques C, Tavares AS, De Bonis M, Covelo P, Martínez-Cedeira J, López A, Sequeira M, Vingada J, Eira C.   +16 more
europepmc   +1 more source