Results 291 to 300 of about 5,067,781 (348)

Prehospital Tranexamic Acid for Severe Trauma.

New England Journal of Medicine, 2023
BACKGROUND Whether prehospital administration of tranexamic acid increases the likelihood of survival with a favorable functional outcome among patients with major trauma and suspected trauma-induced coagulopathy who are being treated in advanced trauma ...
R. Gruen, B. Mitra, Stephen A. Bernard, C. Mcarthur, B. Burns, D. Gantner, M. Maegele, Peter A Cameron, B. Dicker, A. Forbes, S. Hurford, Catherine A Martin, Stefan M Mazur, R. Medcalf, L. Murray, P. Myles, Sze J Ng, V. Pitt, S. Rashford, M. Reade, A. Swain, T. Trapani, P. Young   +22 more
semanticscholar   +1 more source

Tranexamic acid for trauma [PDF]

The Lancet, 2011
The CRASH-2 trial (July 3, p 23) showed reduced trauma mortality through the simple and cheap inter vention of tranexamic acid, placing it into a growing list of options for managing the acute coagulopathy of trauma. This list includes fresh frozen plasma, cryoprecipitate, platelets, fi brinogen, thrombin, prothrombin complexes, recombinant factor VIIa,
Russell L. Gruen, Biswadev Mitra
openaire   +2 more sources

Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders

Expert Opinion on Drug Delivery, 2023
Introduction Tranexamic acid is used for the treatment of hyperpigmentation, and the topical route is the most favorable route for its administration. Tranexamic acid lowers plasmin and tyrosinase, which reduces melanin and skin hyperpigmentation.
P. Verma, K. Yadav
semanticscholar   +1 more source

To Tranexamic Acid or Not to Tranexamic Acid? Accuracy of Antifibrinolytic Administration at Altitude

Air Medical Journal, 2022
Tranexamic acid (TXA) has demonstrated a reduction in all-cause mortality in trauma patients with hemorrhage. Administering TXA in the prehospital setting presents unique challenges because the identification of bleeding is based on clinical suspicion without advanced imaging or diagnostic tools.
Joseph DeVitis, Aaron Ziegler, Chad Barnhart, Alistair Chapman, Cathryn Chadwick, Matthew Dull, Charles Gibson, Tracy J. Koehler, Alan T. Davis, Gaby Iskander, Steffen Pounders, Laura Krech, Chelsea Starr Fisk   +12 more
openaire   +2 more sources

The uses of tranexamic acid in dermatology: a review

International Journal of Dermatology, 2022
Tranexamic acid is a plasmin inhibitor that is used off‐label for the treatment of melasma. The use of tranexamic acid has expanded in the field of dermatology based on its anti‐inflammatory and anti‐melanin‐producing properties, which include the ...
Katelyn M Kim, H. Lim
semanticscholar   +1 more source

Tranexamic Acid in Oncology

Annals of Pharmacotherapy, 1996
Tranexamic acid has the potential to be a pharmacologic adjunct for the prophylaxis of hemorrhagic complications occurring in the oncology population. The studies and cases reviewed here suggest that tranexamic acid administration may be a therapeutic option for bleeding prophylaxis in APL where enhanced fibrinolysis accompanies the disease state ...
Arnold H. Seto, Donna S Dunlap
openaire   +2 more sources

Tranexamic acid in gynecologic surgery

Current Medical Research and Opinion, 2020
Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited references involving TXA and ...
Meir Jonathon Solnik, Andrew Zakhari, Ari P. Sanders, Ari P. Sanders   +3 more
openaire   +2 more sources

Tranexamic acid for percutaneous nephrolithotomy

Cochrane Database of Systematic Reviews, 2022
Percutaneous nephrolithotomy (PCNL) is the gold standard for the treatment of large kidney stones but comes with an increased risk of bleeding compared to other treatments, such as ureteroscopy and shock wave lithotripsy. Tranexamic acid (TXA) is an antifibrinolytic agent that has been used to reduce bleeding complications in other settings.To assess ...
Brent, Cleveland, Brett, Norling, Hill, Wang, Vardhil, Gandhi, Carrie L, Price, Michael S, Borofsky, Vernon, Pais, Philipp, Dahm   +7 more
openaire   +2 more sources

Tranexamic acid in hip hemiarthroplasty

Injury, 2020
Intraoperative use of tranexamic acid (TXA) has been proven to reduce the administration of allogenic blood transfusion in total joint arthroplasty (TJA) patients. Data on TXA efficacy in reducing blood loss in trauma patients undergoing hip hemiarthroplasty are sparse, and its use is not yet well-established.
Itay Ashkenazi, Haggai Schermann, Aviram Gold, Ran Lin, Itay Pardo, Ely Steinberg, Amir Sternheim, Nimrod Snir   +7 more
openaire   +2 more sources

Tranexamic Acid for Postpartum Bleeding

Obstetric Anesthesia Digest, 2011
The randomized controlled trial of the effect of tranexamic acid (TXA) on blood loss during and after cesarean delivery reported by Movafegh et al. [1] in this issue of IJGO is clinically important for two reasons. First, because hemorrhage is a serious complication of cesarean delivery and their data show that bleeding can be reduced by TXA ...
Katharine Ker, Ian Roberts
openaire   +4 more sources