Beyond the Epidural: Reframing Analgesia for the Modern Oesophagectomy
ANZ Journal of Surgery, EarlyView.A novel analgesic framework for minimally invasive oesophagectomy to facilitate functional recovery.
William Thomas Birkett +6 more
wiley +1 more source
Low-Dose Clozapine Reduces Aggression in Violent Substance Use Disorder Patients at a Secure Rehabilitation Center. [PDF]
Case Rep PsychiatryYousuf SM +4 more
europepmc +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo +13 more
wiley +1 more source
Sustainability in Healthcare: The Role of Digital Technologies for Improving Patient Engagement
Business Ethics, the Environment &Responsibility, EarlyView.ABSTRACT Sustainability in healthcare is getting considerable research attention as systems worldwide tend to balance environmental, social, and economic factors. In this context, digital technologies have demonstrated significant potential to enhance engagement among different consumer groups across various industries.
Francesco Schiavone +4 more
wiley +1 more source
Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial
BJU International, Volume 135, Issue 4, Page 638-647, April 2025.Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui +2 more
wiley +1 more source
British Journal of Learning Disabilities, EarlyView.ABSTRACT Background Challenging behaviours (CBs) are known to adversely affect life satisfaction among individuals with intellectual disabilities. Little is known about the impact of different profiles of CBs amongst individuals with intellectual disabilities in South Korea.
Yesang Cho
wiley +1 more source
Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking. [PDF]
Medicine (Baltimore)Liu S, Zhang Z.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito +6 more
wiley +1 more source
In-silico receptor interactions, phytochemical fingerprint and biological activities of Matricaria chamomilla flower extract and the main components. [PDF]
Sci RepAyhan BS, Yalçin E, Çavuşoğlu K.
europepmc +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source