International Journal of Gynecology &Obstetrics, EarlyView.Abstract For six decades, pregnant women have been routinely excluded from pharmaceutical clinical trials, a practice rooted in a protectionist ethic that emerged after the thalidomide tragedy. This narrative review examines whether that exclusion remains ethically justifiable, drawing on the obstetric, pharmacological, and bioethical literature ...
Camila Kruger Cabar +1 more
wiley +1 more source
Pharmacotherapy for psychiatric inpatients with alcohol use disorder or acute intoxication: results from an observational pharmacovigilance program-status and changes between 2000 and 2016. [PDF]
J Neural Transm (Vienna)Haack B +11 more
europepmc +1 more source
Skin‐like ultra‐sensitive gas flow sensing based on ionically conductive organogels
InfoMat, EarlyView.An elaborately designed gas flow sensor based on organogels was employed to precisely monitor trace gas flow disturbances. Leveraging a reversible ion‐mediated cooperative effect, the skin‐like gas flow sensor exhibited excellent sensing performance toward gas flow, featuring low operation voltage and high sensitivity.
Jiaying Yun +11 more
wiley +1 more source
Pharmacotherapy of psychiatric inpatients with mental and behavioral disorders caused by sedatives or hypnotics (F13): Results from an observational pharmacovigilance program between 2000 and 2017. [PDF]
Addict Sci Clin PractPauwels P +9 more
europepmc +1 more source
iNew Medicine, EarlyView.This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin +10 more
wiley +1 more source
Medetomidine Administration at the Subcutaneous GV20 Acupoint Compared with the Intramuscular Route in Guinea Pigs (Cavia porcellus): Sedation Score, Onset, and Duration of Action. [PDF]
J Am Assoc Lab Anim SciEsjaita EI +7 more
europepmc +1 more source
Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility
Journal of Applied Toxicology, EarlyView.ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues +3 more
wiley +1 more source
Exploring Colombian medicinal flora used in indigenous and campesino health systems for neuropsychiatric disorders and neuropharmacological potential: an ethnopharmacological review. [PDF]
Front PharmacolBrache K, Diazgranados M.
europepmc +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Modern agricultural practices expose humans and the environment to numerous chemical pesticides. Increasing evidence suggests that commercial pesticide formulations may exhibit toxicological properties that differ from those of their active ingredients alone due to the presence of co‐formulants and additives. This study evaluated the cytotoxic
Fares Elghali +3 more
wiley +1 more source
Parenteral medication for the management of acute severe behavioural disturbance (ASBD) in the emergency department. [PDF]
Cochrane Database Syst RevBourke E +6 more
europepmc +1 more source