Results 171 to 180 of about 880,312 (268)

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

open access: yesAdvanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng   +6 more
wiley   +1 more source

Sticky Yet Slippery: Molecular Ordering Reconciles Bubble‐Surface Affinity With Ultralow Friction at the Nanoscale

open access: yesAdvanced Science, EarlyView.
By engineering the molecular order and thickness of PDMS layers, we reconcile the stickiness and slipperiness during bubble transport. AFM measurements and MD simulations further reveal how these nanoscale architectures tune hydrophobic interaction FHB and friction force f.
Shishuang Zhang   +7 more
wiley   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

open access: yesAdvanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu   +7 more
wiley   +1 more source

Divergent jejunal cis- and trans-eQTLs and their microbiome associations following a diet lacking mineral phosphorus supplements in laying hens. [PDF]

open access: yesBMC Genomics
Abitew YA   +11 more
europepmc   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

open access: yesAdvanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu   +8 more
wiley   +1 more source

Airway secretory cells contain both a perinuclear Golgi ribbon and dispersed Golgi satellites. [PDF]

open access: yesAm J Respir Cell Mol Biol
Hoang ON   +24 more
europepmc   +1 more source

Integrated Ultrasonic Platform for Bioelectronic Control through Biological Barriers Based on Metasurface

open access: yesAdvanced Science, EarlyView.
A metasurface‐enabled ultrasonic platform achieves precise multi‐focal control through biological barriers, real‐time physiology‐driven modulation, and simultaneous wireless power and data transmission. By unifying wavefront engineering, closed‐loop feedback, and acoustic communication, this work establishes key enabling technologies toward scalable ...
Chuanxin Zhang   +3 more
wiley   +1 more source

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