Results 51 to 60 of about 247,852 (312)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

مستقبل الميتافيرس فى المعاملات البنكية [PDF]

Al-Mağallaẗ Al-Dawliyyaẗ Lil Fiqh wa Al-Qaḍā' wa Al-Tašrīʿ
تعتبر تقنية الميتافيرس أحد أهم أوجه الرقمنة والتحول التكنولوجي الذي تتسارع وتيرته الآن ويشهده العالم أجمع من أقصى الشرق إلى أقصى الغرب، في كل قطاعات ومناحي الحياة بحكم قدرتها على تشكيل الحياة الواقعية من جديد من خلال دمجها مع تكنولوجيا العالم الافتراضي ...
أحمد رجب عبد الخالق قرشم قرشم
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

L’économie volitive de John R. Commons dans Legal Foundations of Capitalism

Œconomia
In Legal Foundations of Capitalism (1924), John R. Commons proposes a volitional theory of economic activity in which the connection between law and economics is central.
Jean-Jacques Gislain
doaj   +1 more source

UNE INTERPRETATION DU TAUX DE CHANGE [PDF]

CES Working Papers, 2015
Dans l’étude ci-dessous on a été réalisé une interprétation de l'impact des fluctuations des taux de change du leu moldave (MDL) sur certaines variables économiques. La période considérée est Novembre-Décembre 2014 et le début de l'année 2015.
Galina ULIAN , Lucia CASTRAVET , Silvestru MAXIMILIAN   +2 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Characters’ Transactional Analysis in Shir-va-Gav (lion and cow) Story (one of Kelile-va-Demne stories) [PDF]

متن شناسی ادب فارسی, 2012
Transactional analysis is a theory for recognizing people's behavior, feeling, and subjectivity in the context of characters' relations in which an image of humans' psychological structure is offered and the triple pattern of carnal states, that is ...
a razi, s hajati
doaj