Results 51 to 60 of about 45,195 (269)
In the summer of 1670, the committee responsible for drafting the criminal ordinance – which would be promulgated a few weeks later – met for its final conference.
Stéphanie Blot-Maccagnan
doaj +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Transactional Tasks: Parallelism in Software Transactions.
Many programming languages, such as Clojure, Scala, and Haskell, support different concurrency models. In practice these models are often combined, however the semantics of the combinations are not always well-defined. In this paper, we study the combination of futures and Software Transactional Memory.
Janwillem Swalens +2 more
openaire +5 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Transaction market multiples are widely used as benchmarks for negotiation between buyers and sellers. This research focuses on financial performance expressed as transaction market multiples of sales, EBITDA and net profit for the 2002-2009 period.
Francis Declerck
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Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
L’économie volitive de John R. Commons dans Legal Foundations of Capitalism
In Legal Foundations of Capitalism (1924), John R. Commons proposes a volitional theory of economic activity in which the connection between law and economics is central.
Jean-Jacques Gislain
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UNE INTERPRETATION DU TAUX DE CHANGE [PDF]
Dans l’étude ci-dessous on a été réalisé une interprétation de l'impact des fluctuations des taux de change du leu moldave (MDL) sur certaines variables économiques. La période considérée est Novembre-Décembre 2014 et le début de l'année 2015.
Galina ULIAN +2 more
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