Results 101 to 110 of about 366,682 (319)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A sharding blockchain protocol for enhanced scalability and performance optimization through account transaction reconfiguration

open access: yesJournal of King Saud University: Computer and Information Sciences
Sharding is a critical technology for enhancing blockchain scalability. However, existing sharding blockchain protocols suffer from a high cross-shard ratio, high transaction latency, limited throughput enhancement, and high account migration. To address
Jiaying Wu   +3 more
doaj   +1 more source

Toward a General Distributed Messaging Framework for Online Transaction Processing Applications

open access: yesIEEE Access, 2017
This paper presents a general distributed messaging framework for online transaction processing applications in e-business industry, and we name it as Metamorphosis (MetaQ).
Jianwei Liao   +3 more
doaj   +1 more source

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih   +40 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer   +14 more
wiley   +1 more source

Blockchain transaction refinery: a traceability refinement mechanism to improve the analysis of permissioned blockchain transactions

open access: yesJournal of King Saud University: Computer and Information Sciences
Blockchain technology is widely used in financial technology and Internet of Things (IoT) security to ensure data integrity, enhance traceability, and develop highly secure systems.
Joonseok Park   +2 more
doaj   +1 more source

AN AGENT BASED TRANSACTION PROCESSING SCHEME FOR DISCONNECTED MOBILE NODES [PDF]

open access: yesICTACT Journal on Communication Technology, 2010
We present a mobile transaction framework in which mobile users can share data which is stored in the cache of a mobile agent. This mobile agent is a special mobile node which coordinates the sharing process.
J.L. Walter Jeyakumar, R.S. Rajesh
doaj  

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein   +7 more
wiley   +1 more source

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