RAD50 missense variants differentially affect the DNA damage response and mitotic progression
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Enhancing blockchain scalability with snake optimization algorithm: a novel approach
Scalability remains a critical challenge for blockchain technology, limiting its potential for widespread adoption in high-demand transactional systems.
Shimal S. H. Taher +2 more
doaj +1 more source
Memristor Crossbar-based Hardware Implementation of IDS Method
Ink Drop Spread (IDS) is the engine of Active Learning Method (ALM), which is the methodology of soft computing. IDS, as a pattern-based processing unit, extracts useful information from a system subjected to modeling. In spite of its excellent potential
Bagheri-Shouraki, Saeed +2 more
core +1 more source
NewSQL: Towards Next-Generation Scalable RDBMS for Online Transaction Processing (OLTP) for Big Data Management [PDF]
One of the key advances in resolving the big-data problem has been the emergence of an alternative database technology. Today, classic RDBMS are complemented by a rich set of alternative Data Management Systems (DMS) specially designed to handle the ...
A. Moniruzzaman
semanticscholar +1 more source
The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman +3 more
wiley +1 more source
Why emerging leaders should focus on being good postdoctoral supervisors
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski +5 more
wiley +1 more source
The problem of transaction processing using microservice architecture
Background. The object of the research is an e-commerce system built on the principle of microservice architecture. The subject of the research is methods of ensuring correct operation of transactions using a microservice architecture.
D.S. Fomin, A.V. Bal'zamov
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Studi Kelayakan Pengembangan Pasar Hewan Di Kabupaten Bekasi [PDF]
Animal/Cattle market which is the the place where the breeder, trader, and collector between regions conduct animal buying and selling transaction, also has function to do animal trading that is traded and applies transparant mechanism transaction with ...
Nuryono, R. (Rahmat)
core +2 more sources
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source

