Results 51 to 60 of about 4,858,194 (302)

State of the art and future research on distributed processing system in Internet environment

open access: yes大数据, 2018
Due to the gradual failure of Moore’s law,traditional centralized data processing systems begin to show performance bottlenecks,which can’t effectively support the rapid development of current business.At the same time,due to the security,cost,policy and
Pengwei MA, Kai WEI, Chunyu JIANG
doaj  

Design of accounting information system sales [PDF]

open access: yes, 2011
The rapid development of science and technology led to the use of computers increasingly dominant and universal.Today the computer is very helpful in all aspects of human life, especially to facilitate the activity, especially at work.In the computer ...
Firdaus, Dony Waluya
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Rancang Bangun Engine ETL Data Warehouse dengan Menggunakan Bahasa Python

open access: yesJurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2019
Big companies that have many branches in different locations often have difficulty with analyzing transaction processes from each branch. The problem experienced by the company management is the rapid delivery of massive data provided by the branch to ...
I Made Suwija Putra   +1 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

APLIKASI TRANSAKSI VOUCHER MENGGUNAKAN RFID DAN FINGERPRINT [PDF]

open access: yes, 2009
Nowdays that modern and technology has applied to everyday life. So people have been spoiled with facilities and public services are fast and reliable.
Ardilla, Fernando   +2 more
core  

Home - About - Disclaimer - Privacy