Results 51 to 60 of about 3,710 (244)

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

open access: yesAdvanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu   +9 more
wiley   +1 more source

Patient delays in seeking help at the onset of rheumatoid arthritis: the problem, its causes and potential solutions

open access: yes, 2013
Rheumatoid arthritis (RA) is a chronic inflammatory disease for which early treatment is vital to limit long term joint damage. However, people often delay in seeking medical help at the onset of RA symptoms.
Stack, Rebecca   +8 more
core   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

open access: yesAdvanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang   +11 more
wiley   +1 more source

The theory of forms and Plato's ethics

open access: yes, 2012
Includes abstract.Includes bibliographical references.The aims of this dissertation are to uncover and analyse potential links between ethics and metaphysics - specifically, the theory of Forms - in the dialogues of Plato. Drawing on material from a wide
Sinclaire, Jennifer
core  

Self-Enhancement and Self-Transcendence Organizational Values' Effects on Customer Satisfaction and Corporate Reputation [PDF]

open access: yes, 2013
While organizational values and their implications for organizational effectiveness and employee outcomes have been studied at length within the management literature, the question of how organizational values influence marketing outcomes remains under ...
Bell, Monique L.
core  

A Pollen‐Enhanced Bionic Mechanoreceptor Induced by Asymmetric Ionic Convection in Hydrogel for Sensory‐Augmented Prostheses

open access: yesAdvanced Science, EarlyView.
This work proposed a pollen‐enhanced bionic mechanoreceptor based on ionic convection. Leveraging the ion anchoring effect of the pollen particle, the output performance could be ∼12 times higher than the original state. By employing deep learning models as AI brains, the feasibility of a sensory‐augmented prosthesis consisting of a pollen‐enhanced ...
Zi Hao Guo   +7 more
wiley   +1 more source

Studi Integrasi Islam, Sains, dan Budaya Nusantara Perspektif Pendidikan Profetik: Menilik Podcast “Beranda Islami” Fakultas Dakwah UIN Profesor Kiai Haji Saifuddin Zuhri Purwokerto

open access: yesJurnal Kependidikan
Islam is able to answer all problems following the development of science and technology so that scientific integrations become a necessity. Worship is related to knowing himself, others, nature, and God.
Mauliya Nandra Arif Fani, Moh. Roqib
doaj   +1 more source

Habitus and Reflexivity: Restructuring Bourdieu's Theory of Practice [PDF]

open access: yes
Contrary to Bourdieu\'s thesis, it is not only when a subject\'s habitus does not fit a field\'s positions that s/he becomes more reflexive. Reflexivity is also enhanced by intra-habitus tensions, by more general incongruences between dispositions ...
Nicos Mouzelis
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou   +12 more
wiley   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu   +8 more
wiley   +1 more source

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