Results 111 to 120 of about 390 (152)
Calcium dependencies in the binding of transcobalamins to subcellular particles of liver cells
, 1979 William S. Beck, Carter M. Becker
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Some of the next articles are maybe not open access.
Expression of transcobalamin II by amniocytes
Prenatal Diagnosis, 1987AbstractChildren with a genetic absence of transcobalarnin 2 (TC2) are clinically asymptomatic at birth but develop severe megaloblastic anemia early in life. We have examined the incorporation of [57Co]‐CN‐B12 in the absence of any exogenous source of TC2 in control amniotic fluid derived cells and cultured diploid fibroblasts, and in fibroblasts from
D S, Rosenblatt, A, Hosack, N, Matiaszuk
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The origin and clinical implications of vitamin B12 binders - the transcobalamins
, 1979 M. Schlesinger +3 more
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Transcobalamin II deficiency at birth
Molecular Genetics and Metabolism, 2009Transcobalamin II deficiency (# MIM 275350) is a rare, recessively inherited disorder of cobalamin transport that leads to intracellular cobalamin depletion with secondary impairment of methionine synthetase and methyl-malonyl CoA mutase activities.
Ratschmann, Rene +8 more
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Transcobalamin polymorphism and homocysteine
Blood, 2001Namour et al[1][1] suggest that codon 259 of the transcobalamin (TC) gene is a major determinant of TC polymorphism in Caucasians and that heterozygous individuals have higher plasma homocysteine.
Andrew McCaddon +4 more
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Scandinavian Journal of Haematology, 1977
Insolubilized antibody to transcobalamin I was used to separate transcobalamin I and transcobalamin II. By bioautography of the extracted cobalamins it was shown that transcobalamin II bound more deoxyadenosylcobalamin than did transcobalamin I, and that methylcobalamin accounts for most of the cobalamins attached to transcobalamin I.
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Insolubilized antibody to transcobalamin I was used to separate transcobalamin I and transcobalamin II. By bioautography of the extracted cobalamins it was shown that transcobalamin II bound more deoxyadenosylcobalamin than did transcobalamin I, and that methylcobalamin accounts for most of the cobalamins attached to transcobalamin I.
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4 Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex
Baillière's Clinical Haematology, 1995Summary Transcobalamin II is a plasma protein that binds vitamin B 12 (cobalamin) as it is absorbed in the terminal ileum and distributes it to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis.
Sheldon P. Rothenberg, Edward V. Quadros
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Clinical Chemistry and Laboratory Medicine, 2013
Plasma cobalamin is requested in order to diagnose cobalamin deficiency and low levels confirm a deficient state. Here, we present three family members with unexpected high levels of cobalamin.We included a patient referred for cobalamin measurement due to neurological symptoms, her son and her daughter.
Hoffmann-Lücke, Elke; id_orcid 0000-0002-2437-0140 +5 more
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Plasma cobalamin is requested in order to diagnose cobalamin deficiency and low levels confirm a deficient state. Here, we present three family members with unexpected high levels of cobalamin.We included a patient referred for cobalamin measurement due to neurological symptoms, her son and her daughter.
Hoffmann-Lücke, Elke; id_orcid 0000-0002-2437-0140 +5 more
openaire +3 more sources
Biochimica et Biophysica Acta (BBA) - General Subjects, 1976
Assay of the reactivity between the chicken anti-rabbit transcobalamin II antiserum and the sera of 19 vertebrate species was carried out by both immuno-diffusion and Sephadex G-200 gel filtration column chromatography. Mammalian transcobalamin II cross-reacted with the antiserum whereas the serum vitamin B-12 binders of the bird, amphibian reptile and
C H, Tan, S J, Blaisdell
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Assay of the reactivity between the chicken anti-rabbit transcobalamin II antiserum and the sera of 19 vertebrate species was carried out by both immuno-diffusion and Sephadex G-200 gel filtration column chromatography. Mammalian transcobalamin II cross-reacted with the antiserum whereas the serum vitamin B-12 binders of the bird, amphibian reptile and
C H, Tan, S J, Blaisdell
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Biochemical and Biophysical Research Communications, 1995
Human transcobalamin II (TC II) gene was isolated and partially sequenced. The gene is composed of nine exons and eight introns spanning approximately 20 kb. Multiple potential transcription start sites were revealed by primer extension analysis. The 5'-flanking region of the gene contained no TATA-like motif, but a binding motif for HIP1, which is ...
N, Li, S, Seetharam, B, Seetharam
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Human transcobalamin II (TC II) gene was isolated and partially sequenced. The gene is composed of nine exons and eight introns spanning approximately 20 kb. Multiple potential transcription start sites were revealed by primer extension analysis. The 5'-flanking region of the gene contained no TATA-like motif, but a binding motif for HIP1, which is ...
N, Li, S, Seetharam, B, Seetharam
openaire +2 more sources