Advanced Science, EarlyView.This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang +20 more
wiley +1 more source
Noninvasive Brain Stimulation and Personal Identity: Ethical Considerations. [PDF]
, 2017 As noninvasive brain stimulation (NIBS) technology advances, these methods may become increasingly capable of influencing complex networks of mental functioning. We suggest that these might include cognitive and affective processes underlying personality
Iwry, Jonathan +2 more
core +3 more sources
Advanced Science, EarlyView.Laser ultrasound super‐resolution imaging (LUSSI) leverages laser‐generated ultrasound for functional 3D transcranial imaging of brain tumor vasculature. Combined with optoacoustic tomography, it is demonstrated in a glioblastoma model, revealing structural abnormalities, compressed vessels, hemorrhages, and hypoxic regions.
Daniil Nozdriukhin +4 more
wiley +1 more source
The Effect of Combining Transcranial Direct Current Stimulation Treatment and an Exercise Program on Fragility in a Population with Multiple Sclerosis: Cross-Over Design Trial [PDF]
, 2022 Inés Muñoz-Paredes +4 more
openalex +1 more source
Deontological morality can be experimentally enhanced by increasing disgust. A transcranial direct current stimulation study [PDF]
, 2018 Previous studies empirically support the existence of a distinctive association between deontological (but not altruistic) guilt and both disgust and obsessive-compulsive (OC) symptoms.
Collazzoni, Alberto +4 more
core +1 more source
Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
Advanced Science, EarlyView.LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins
Advanced Science, EarlyView.As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan +14 more
wiley +1 more source
Towards Targeted Brain Stimulation in Stroke: Connectivity as a Biomarker of Response
Journal of Experimental Neuroscience, 2018 Stroke is a leading cause of adult disability. New treatments capable of assisting recovery hold significant potential to improve quality of life for many stroke survivors.
Brenton Hordacre +2 more
doaj +1 more source
Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis [PDF]
, 2023 Francisco Gurdiel‐Álvarez +6 more
openalex +1 more source
Advanced Science, EarlyView.This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang +19 more
wiley +1 more source