Results 91 to 100 of about 169 (168)

Two‐year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to report on the long‐term safety and efficacy of epicranial focal cortex stimulation (FCS) using the EASEE device as adjunctive neuromodulatory therapy in improving seizure control in adults with pharmacoresistant epilepsy originating from one predominant epileptogenic zone.
Andreas Schulze‐Bonhage, Martin Hirsch, Susanne Knake, Ann Mertens, Michael Rademacher, Elisabeth Kaufmann, Josua Kegele, Carolin Jenkner, Volker Coenen, Martin Glaser, Sergiu Groppa, Yaroslav Winter, for the EASEE Study Group   +12 more
wiley   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications. 1. Use of the EEG in drug development and characteristics of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof‐of‐principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalography (EEG) response (PPR) as a surrogate for seizures, is currently the only human model that allows POP trials of investigational compounds after ...
Dorothée Kasteleijn‐Nolst Trenité, Wolfgang Löscher   +1 more
wiley   +1 more source

Learning from missteps: Potential of transcranial electrical stimulation in neuropsychological rehabilitation

Journal of Neuropsychology, EarlyView.
Abstract Transcranial electrical stimulation (tES) holds promise for neuropsychological rehabilitation by leveraging the brain's inherent plasticity to enhance cognitive and motor functions. However, early results have been variable due to oversimplified approaches.
Carlo Miniussi, Maria Concetta Pellicciari   +1 more
wiley   +1 more source

NREM Sleep Oscillations Are Associated With Anxiety and Negative Affect in Young Adults

Journal of Sleep Research, EarlyView.
ABSTRACT Non‐rapid eye movement sleep (NREM) oscillations are critical for cognitive and affective processing. While several studies link anxiety and depression symptoms to sleep quality, a critical gap remains in elucidating the role of NREM physiology in sleep‐dependent processing of affect and anxiety symptoms. The goals of the present study were to
Hazal Arpaci, Nandita Banik, Pinar Kurdoglu Ersoy, Ciara Harrington, Aycan Kapucu, Bengi Baran   +5 more
wiley   +1 more source

The Future of Non‐Invasive Brain Stimulation in Sleep Medicine

Journal of Sleep Research, EarlyView.
ABSTRACT Non‐invasive brain stimulation (NIBS) methods carry particular appeal as non‐pharmacological approaches to inducing or improving sleep. However, intense research efforts to use transcranial magnetic stimulation (TMS) and electrical stimulation (tES) for sleep modulation have not yet delivered evidence‐based NIBS treatments in sleep medicine ...
Lukas B. Krone, Seo Ho Song, Valeria Jaramillo, Ines R. Violante   +3 more
wiley   +1 more source

The Future of Parasomnias

Journal of Sleep Research, EarlyView.
ABSTRACT Parasomnias are abnormal behaviours or mental experiences during sleep or the sleep–wake transition. As disorders of arousal (DOA) or REM sleep behaviour disorder (RBD) can be difficult to capture in the sleep laboratory and may need to be diagnosed in large communities, new home diagnostic devices are being developed, including actigraphy ...
Claudia Picard‐Deland, Matteo Cesari, Ambra Stefani, Jean‐Baptiste Maranci, Birgit Hogl, Isabelle Arnulf   +5 more
wiley   +1 more source

Evidence‐based review and frontiers of migraine therapy

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
Abstract Background Cyclic vomiting syndrome (CVS) is identified as one of the “episodic syndromes that may be associated with migraine,” along with benign paroxysmal torticollis, benign paroxysmal vertigo, and abdominal migraine. It has been proposed that CVS and migraine may share pathophysiologic mechanisms of hypothalamic activation and altered ...
Kaitlin A. Greene, Amy A. Gelfand, Larry Charleston IV   +2 more
wiley   +1 more source

Future Applications of Central Neuromodulation and Neurophysiological Testing in Cyclic Vomiting Syndrome

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
ABSTRACT Background Cyclic vomiting syndrome (CVS) is defined by its episodic patterning. Furthermore, CVS is associated with other episodic disorders such as migraine and epilepsy. Indeed, many of the medications that are known to be useful for prophylaxis and abortive therapy in CVS are also effective in preventing and aborting migraines and seizures.
David J. Levinthal, Braden Kuo
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source