Results 191 to 200 of about 34,559 (265)

Real‐World Effectiveness and Cost‐Differential of Intranasal Esketamine Versus Intramuscular Ketamine

open access: yesPsychiatric Research and Clinical Practice, EarlyView.
Objective This study evaluated whether intramuscular (IM) ketamine is non‐inferior to intranasal (IN) esketamine for treatment‐resistant depression (TRD) and assessed differences in safety and healthcare costs. Methods In a retrospective, observational sequential cohort at the VA San Diego, 179 Veterans with TRD received eight treatments of either IN ...
Kush V. Bhatt   +12 more
wiley   +1 more source

Models Containing the Braden Scale Predict Activities of Daily Living Improvement in Post‐Stroke Hemiplegia: A Single Center Retrospective Cohort Study

open access: yesPhysiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Background and Purpose This study sought to develop and validate a predictive model integrating the Braden scale to forecast the recovery of activities of daily living (ADL) in patients with post‐stroke hemiplegia. Additionally, it aimed to evaluate the effectiveness of a comprehensive rehabilitation program.
Yuanyuan Zhu   +6 more
wiley   +1 more source

Upper‐Limb Paresis Severity Is Associated With Practice Dosage During Task‐Oriented Training in Subacute Stroke—An Exploratory Secondary Analysis

open access: yesPhysiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Background and Purpose Intensive, high‐repetition practice is one of the strategies incorporated into upper‐limb task‐oriented training (UL‐TOT) to promote experience‐dependent neural plasticity after stroke. Although a target of 300 repetitions during a one‐hour UL‐TOT session is feasible, considerable variability in the practice dosage ...
Subramanian Durairaj   +3 more
wiley   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba   +7 more
wiley   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

open access: yesJournal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

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