Results 41 to 50 of about 276,086 (232)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Metabolic Syndrome and Dementia Risk in Older Adults: A Narrative Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Dementia is a major global health issue in aging societies. Metabolic syndrome (MetS), a cluster of metabolic abnormalities, has been proposed as a modifiable risk factor for dementia, although existing evidence remains inconsistent. This review examined recent studies on the association between MetS and dementia risk in older adults.
Hyojin Park, Mallika Chuansangeam, Yuan‐Han Yang   +2 more
wiley   +1 more source

Whole‐Brain Cerebral Microvascular Pulsatility Imaging Using Dynamic pCASL MRI With Segmented Stack‐of‐Stars Golden‐Angle Radial Acquisition

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop an efficient dynamic pseudo‐continuous arterial spin labeling (pCASL) MRI technique for whole‐brain microvascular flow pulsatility imaging. Methods The proposed technique combines pCASL with a segmented stack‐of‐stars golden‐angle radial acquisition.
Tianrui Zhao, Jianing Tang, Yining He, Dilip K. Pandey, Philip B. Gorelick, Lirong Yan   +5 more
wiley   +1 more source

Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia
Background: The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown.
André Rolim Belisário, Rahyssa Rodrigues Sales, Nayara Evelin Toledo, Cibele Velloso-Rodrigues, Célia Maria Silva, Marcos Borato Viana   +5 more
doaj   +1 more source

Transcranial doppler ultrasonography in neurocysticercosis

Arquivos de Neuro-Psiquiatria
Hinpetch Daungsupawong, Viroj Wiwanitkit
doaj   +4 more sources

S-Nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty [PDF]

, 2002
Background: The major complication of carotid angioplasty is embolic stroke, which may occur after balloon inflation and deflation or in the early postintervention period.
Clifton, A., Markus, H.S., Martin, J.F., Kaposzta, Z., Molloy, J.   +4 more
core  

Determination of hemispheric dominance with mental rotation using functional transcranial Doppler sonography and FMRI

, 2010
the aim of this study was to investigate specific activation patterns and potential gender differences during mental rotation and to investigate whether functional magnetic resonance imaging (fMRI) and functional transcranial Doppler sonography (fTCD ...
Johannes T. Heverhagen, Karl Martin Klein, Anke Hermsen, Rosenow, Felix, Susanne Knake, Felix Rosenow, Hattemer, Katja, Heverhagen, Johannes T, Klein, Karl Martin, Plate, Annika, Keil, Boris, Wolfgang H. Oertel, Haag, Anja, Knake, Susanne, Hermsen, Anke, Oertel, Wolfgang H, Anja Haag, Annika Plate, Hamer, Hajo M, Boris Keil, Katja Hattemer, Hajo M. Hamer, Heverhagen, Johannes   +22 more
core   +1 more source

Optimum timing of cerebral computed tomography angiography for determination of death using neurological criteria: a retrospective sensitivity cohort study

Anaesthesia, EarlyView.
Summary Introduction Cerebral computed tomography angiography (CTA) is increasingly incorporated into national guidelines to confirm cerebral circulatory arrest during the determination of death using neurological criteria. However, implementation remains limited due to studies showing variable sensitivity.
Romuald Bohatyrewicz, Marcin Sawicki, Katarzyna Chamier‐Ciemińska, Łukasz Zwarzany, Katarzyna Kotfis, Joanna Sołek‐Pastuszka, Klaudyna Kojder, Krzysztof Safranow, Wojciech Walas, Elżbieta Byrska‐Maciejasz, Wojciech Saucha, Joanna Wojczal, Wojciech Dąbrowski, Filip Szeremeta, Wojciech Poncyljusz   +14 more
wiley   +1 more source

Análise da capacidade reactiva da circulação intracerebral pelo efeito do CO2. Um método de fácil execução.

Acta Médica Portuguesa, 1998
Maintenance of cerebral perfusion pressure is a prerequisite for the prevention of cerebral ischaemia. Physiological fluctuations in systemic perfusion pressure are compensated by cerebrovascular autoregulation.
A Baptista, J Ribeiro
doaj   +1 more source

Association of enlarged perivascular space burden with silent cerebral infarcts in children with sickle cell disease

British Journal of Haematology, EarlyView.
Enlarged perivascular spaces (ePVS) in the basal ganglia and centrum semiovale are highly prevalent in children with sickle cell disease (SCD). Enlarged PVS in the basal ganglia are associated with the presence of silent cerebral infarcts, another marker of neurological disease, in children with SCD. Summary Children with sickle cell disease (SCD) have
Kristine A. Karkoska, Jahnavi Gollamudi, Brady J. Williamson, Russell P. Sawyer, Daniel Woo, Achala Vagal, Hyacinth I. Hyacinth   +6 more
wiley   +1 more source