Results 111 to 120 of about 255,609 (202)

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Transcranial Doppler and Color-Coded Doppler Use for Brain Death Determination in Adult Patients: A Pictorial Essay

Transcranial Doppler (TCD) is a repeatable, at-the-bedside, helpful tool for confirming cerebral circulatory arrest (CCA). Despite its variable accuracy, TCD is increasingly used during brain death determination, and it is considered among the optional ...
Vetrugno, Giuseppe, Biasucci, Daniele G
core   +1 more source

Transcranial Doppler Monitoring of Cerebral Blood Velocity During Craniotomy

, 1989
Transcranial Doppler techniques were used to monitor blood velocity in cerebral arteries continuously during 14 neurosurgical operations performed on 13 patients, including 12 craniotomies.
Cole A. Giller
core   +1 more source

Repetitive Transcranial Magnetic Stimulation Combined With Median Nerve Electrical Stimulation for Severe Traumatic Brain Injury

Brain and Behavior, Volume 16, Issue 10, October 2026.
Combining top‐down rTMS over the left DLPFC with bottom‐up right median nerve stimulation markedly outperformed either modality alone, awakening 93% of patients with severe TBI by week 4 and improving EEG, hemodynamics, and GCS—supporting dual‐pathway neuromodulation as a safe, high‐efficacy strategy for coma recovery.
Nana Wang, Manrong Li, Guozhen Zhang
wiley   +1 more source

Integrative regulation of cerebral blood flow in response to exercise and environmental extremes

Experimental Physiology, EarlyView.
Shigehiko Ogoh, Damian M. Bailey
wiley   +1 more source

Natural History and Factors Influencing 90‐Day Clinical Outcomes and 1‐Year Recurrence of Thalamic Stroke

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Objective To investigate the natural course of cerebral small vessel disease (CSVD) manifested as pure thalamic infarction (PTI) and identify predictors of 90‐day clinical prognosis and 1‐year recurrent major adverse cardiovascular/cerebrovascular events (MACE).
Huang Qiang, Cui Ying, Zhang Yongbo
wiley   +1 more source

Transcranial Doppler assessment of cerebral autoregulation and vasomotor reactivity: Usefulness in arterial blood pressure treatment

, 1997
Transcranial Doppler assessment of cerebral autoregulation and vasomotor reactivity: Usefulness in arterial blood pressure ...
P Desfontaines (13444668), FA Van De Wyngaert (14480028), A Peeters (9174206)   +2 more
core  

Cerebral Lateralization for Language as a Potential Biomarker for the Broad Autism Phenotype: A Functional Transcranial Doppler Ultrasonography Investigation

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Introduction Autism spectrum disorder (ASD) is associated with language deficits, while growing evidence suggests that atypical cerebral lateralization for language could serve as a potential neural marker for ASD. The present study seeks to investigate cerebral lateralization for language not only in terms of ASD, but also as a potential ...
Venetia Mendrinou, Anastasia K. Papadopoulou, Ioanna Panopoulou, Filippos Vlachos, Sebastian Ocklenburg, Banu Ahtam, Nicholas A. Badcock, Phivos Phylactou, Marietta Papadatou‐Pastou   +8 more
wiley   +1 more source

The diagnostic performance of transcranial Doppler ultrasound and carotid duplex in the diagnosis of cerebral small vessel disease

The Egyptian Journal of Radiology and Nuclear Medicine
Background and rationale Cerebral small vessel disease is a frequent, long-term, and progressing vascular disease accounting for twenty percent of whole strokes and twenty-five percent of ischemic strokes.
Afaf Mohamed, Sara Gamal, Sama Ayman, Hatem El-Azizi   +3 more
doaj   +1 more source