Results 61 to 70 of about 710,712 (281)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study

Critical Care, 2017
BackgroundUntimely diagnosis of intracranial hypertension may lead to delays in therapy and worsening of outcome. Transcranial Doppler (TCD) detects variations in cerebral blood flow velocity which may correlate with intracranial pressure (ICP).
F. Rasulo, R. Bertuetti, C. Robba, F. Lusenti, A. Cantoni, Marta Bernini, Alan Girardini, S. Calza, S. Piva, N. Fagoni, N. Latronico   +10 more
semanticscholar   +1 more source

Cerebral Hemodynamic Changes in Older Adults With Cognitive Complaints According to the Presence of Peripheral Artery Disease

AGING MEDICINE, EarlyView.
Among 132 older adults, 13 had peripheral artery disease (PAD), identified using the ankle–brachial index. Over approximately 13 months, PAD was associated with increasing middle cerebral artery mean flow velocity, with a significant difference in left‐sided velocity change between groups.
SangMi Noh, Hae‐Eun Shin, YongSoo Shim
wiley   +1 more source

Metabolic Syndrome and Dementia Risk in Older Adults: A Narrative Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Dementia is a major global health issue in aging societies. Metabolic syndrome (MetS), a cluster of metabolic abnormalities, has been proposed as a modifiable risk factor for dementia, although existing evidence remains inconsistent. This review examined recent studies on the association between MetS and dementia risk in older adults.
Hyojin Park, Mallika Chuansangeam, Yuan‐Han Yang   +2 more
wiley   +1 more source

Cerebral Lateralization for Language as a Potential Biomarker for the Broad Autism Phenotype: A Functional Transcranial Doppler Ultrasonography Investigation [PDF]

Brain Behav
ABSTRACT Introduction Autism spectrum disorder (ASD) is associated with language deficits, while growing evidence suggests that atypical cerebral lateralization for language could serve as a potential neural marker for ASD. The present study seeks to investigate cerebral lateralization for language not only in terms of ASD, but also as a potential ...
Mendrinou V, Papadopoulou A, Panopoulou I, Vlachos F, Ocklenburg S, Ahtam B, Badcock N, Phylactou P, Papadatou‐Pastou M.   +8 more
europepmc   +2 more sources

Whole‐Brain Cerebral Microvascular Pulsatility Imaging Using Dynamic pCASL MRI With Segmented Stack‐of‐Stars Golden‐Angle Radial Acquisition

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop an efficient dynamic pseudo‐continuous arterial spin labeling (pCASL) MRI technique for whole‐brain microvascular flow pulsatility imaging. Methods The proposed technique combines pCASL with a segmented stack‐of‐stars golden‐angle radial acquisition.
Tianrui Zhao, Jianing Tang, Yining He, Dilip K. Pandey, Philip B. Gorelick, Lirong Yan   +5 more
wiley   +1 more source

AI‐Based Automated Instrument Tracking During Endoscopic Skull Base Surgery: A Pilot Feasibility Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Endoscopic endonasal approaches (EEA) to skull base tumors are a technically challenging procedure for both surgeons and trainees. Artificial intelligence and computer vision (CV) may offer an objective analysis that provides surgical assessment on technique and enhanced educational feedback for surgeons of all levels.
David R. Grimm, Dhiraj Pangal, Danyal Z. Khan, Margaux Masson‐Forsythe, Kaan Duman, Ayesha Syeda, Jack Cook, Peter H. Hwang, Jayakar Nayak, Zara M. Patel, Noel Ayoub, Robert Dodd, Juan Fernandez‐Miranda, Daniel Donoho, Michael T. Chang   +14 more
wiley   +1 more source

Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia
Background: The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown.
André Rolim Belisário, Rahyssa Rodrigues Sales, Nayara Evelin Toledo, Cibele Velloso-Rodrigues, Célia Maria Silva, Marcos Borato Viana   +5 more
doaj   +1 more source

Impaired Cerebral Haemodynamics in Vascular Depression: Insights From Transcranial Doppler Ultrasonography

Frontiers in Psychiatry, 2018
Introduction: Late-life depression is a well-known risk factor for future dementia. Increasing evidences also show a link between cerebral hypoperfusion and neurodegeneration, although data on Transcranial Doppler ultrasonography (TCD)-derived measures ...
V. Puglisi, A. Bramanti, G. Lanza, Mariagiovanna Cantone, Luisa Vinciguerra, M. Pennisi, L. Bonanno, G. Pennisi, R. Bella   +8 more
semanticscholar   +1 more source

Transcranial doppler sonography and the application in critical care and anesthesia

, 2021
This thesis discusses the application of Transcranial Doppler Sonography in the fields of critical care and anesthesiology. It highlights the mechanism of cerebrovascular hemostasis.
Larinde, Samson
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