Results 151 to 160 of about 146,119 (303)

Efficacy and safety of traditional Chinese medicine aromatherapy for insomnia patients with predominant difficulty in sleep initiation

open access: yesSleep Research, EarlyView.
Abstract Background Insomnia is highly prevalent, and non‐pharmacological strategies to facilitate sleep initiation remain an important clinical priority. Aims This study aimed to evaluate the tolerability, safety, and preliminary sleep‐related effects of a herbal aromatherapy liquid administered using a Traditional Chinese Medicine Aromatherapy Sleep ...
Huafeng Shan   +8 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade   +7 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

open access: yesBritish Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman   +3 more
wiley   +1 more source

Bringing cellular clarity to the cortical component of ALS with a high‐density multi‐electrode array system

open access: yesThe FEBS Journal, EarlyView.
High density multi‐electrode (HD‐MEA) systems enable detailed investigation of healthy and diseased brains in 2D and 3D. Here, we summarise the significance of single‐cell electrophysiology, advantages of the MEA systems with high spatio‐temporal resolution and a large number of recording sites, enabling complex network analysis.
Zehra Yagmur Erol   +2 more
wiley   +1 more source

Clinical Observation on Xingnao Kaiqiao Acupuncture Combined with Repetitive Transcranial Magnetic Stimulation for Post-stroke Speech Dysfunction

open access: yes康复学报, 2017
Objective:To observe the effect of Xingnao Kaiqiao acupuncture combined with repetitive transcranial magnetic stimulation on post-stroke speech dysfunction.Methods:A total of 48 patients with post-stroke speech dysfunction were randomly assigned to the ...
Zhaojun DAN   +4 more
doaj  

Frontal Lobe Epilepsy Presenting With Unilateral Eye Closure

open access: yes
Neurology and Clinical Neuroscience, EarlyView.
Yuki Mizumoto   +6 more
wiley   +1 more source

Slow Wave Activity During Nocturnal Sleep in Hypersomnolence Disorder

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Slow waves during non‐rapid eye movement (NREM) sleep are associated with the restorative aspects of sleep. Previous research has suggested reduced normalized slow wave activity (SWA), particularly in the first cycle of NREM sleep, as a feature of hypersomnolence disorder (HD); however, the scarcity of existing research highlights the need for
Jesse D. Cook   +6 more
wiley   +1 more source

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