Results 201 to 210 of about 5,189,368 (329)

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Targeting rare splicing defects: Antisense oligonucleotides offer a therapeutic strategy in FRDA. [PDF]

Mol Ther Nucleic Acids
Kerkhof LMC, Buijsen RAM.
europepmc   +1 more source

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

Nature, 2011
C. Colantuoni, B. Lipska, Tianzhang Ye, T. Hyde, R. Tao, J. Leek, E. Colantuoni, A. Elkahloun, M. Herman, D. Weinberger, J. Kleinman   +10 more
semanticscholar   +1 more source

Transcription of the Genetic Material

The American Biology Teacher, 1971
openaire   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Molecular Genetics of Primary Congenital Hypothyroidism: Established and Emerging Contributors to Thyroid Dysgenesis. [PDF]

Int J Mol Sci
Dermitzaki N, Serbis A, Baltogianni M, Gialamprinou D, Giaprou LE, Kosmeri C, Giapros V.   +6 more
europepmc   +1 more source

Molecular and genetic control of plant thermomorphogenesis

Nature Plants, 2016
M. Quint, C. Delker, K. Franklin, P. Wigge, K. Halliday, M. V. Zanten   +5 more
semanticscholar   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Engineering genetic elements for microbial protein expression systems: Advances, challenges, applications, and prospects. [PDF]

Synth Syst Biotechnol
Li X, Ye C, Liu T, Li S, Zhang M, Zhao Y, Jin Y, Cheng J, Yang G, Li P.   +9 more
europepmc   +1 more source

Disease variants alter transcription factor levels and methylation of their binding sites

Nature Genetics, 2016
M. Bonder, R. Luijk, D. Zhernakova, M. Moed, Patrick Deelen, M. Vermaat, M. van Iterson, F. van Dijk, M. van Galen, J. Bot, R. Slieker, P. M. Jhamai, M. Verbiest, H. Suchiman, M. Verkerk, R. van der Breggen, J. V. van Rooij, N. Lakenberg, W. Arindrarto, S. Kiełbasa, I. Jonkers, Peter van ’t Hof, I. Nooren, M. Beekman, J. Deelen, D. van Heemst, A. Zhernakova, E. Tigchelaar, M. Swertz, A. Hofman, A. Uitterlinden, R. Pool, J. van Dongen, J. Hottenga, C. Stehouwer, C. V. D. van der Kallen, C. Schalkwijk, L. H. van den Berg, E. V. van Zwet, H. Mei, Yang Li, M. Lemire, T. Hudson, P. Slagboom, C. Wijmenga, J. Veldink, M. V. van Greevenbroek, C. V. van Duijn, D. Boomsma, A. Isaacs, R. Jansen, J. V. van Meurs, P. ’. ’t Hoen, L. Franke, B. Heijmans   +54 more
semanticscholar   +1 more source