Results 221 to 230 of about 5,189,368 (329)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease. [PDF]

Acta Neurol Belg
Nguyen HD.
europepmc   +1 more source

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

Development, 2015
E. Kozhemyakina, A. Lassar, E. Zelzer
semanticscholar   +1 more source

Yeast genetics: Genetic control mechanisms: transcriptional twisting [PDF]

Nature, 1986
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Balancing act: progress and prospects in breeding soybean varieties with high oil and seed protein content. [PDF]

Front Plant Sci
Shi Q, Mo W, Zheng X, Zhao X, Chen X, Zhang L, Qin J, Yang Z, Zuo Z.   +8 more
europepmc   +1 more source

Genetic induction and mechanochemical propagation of a morphogenetic wave

Nature, 2019
Anaïs Bailles, Claudio Collinet, J. Philippe, P. Lenne, E. Munro, Thomas Lecuit   +5 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Clinical and molecular genetic analysis of a Chinese patient with Cockayne syndrome caused by ERCC8 gene synonymous variant at splicing site and exon 1 deletion. [PDF]

Orphanet J Rare Dis
Bie X, Liu L, Liu L, Zhang Z, Guo M, Xie Z, Zhang Y, Su J, Li D.   +8 more
europepmc   +1 more source

Function of MYB domain transcription factors in abiotic stress and epigenetic control of stress response in plant genome

Plant Signalling & Behavior, 2016
Sujit Roy
semanticscholar   +1 more source