Results 281 to 290 of about 5,008,846 (367)

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Expression analysis and functional study of honeysuckle MYB transcription factors under drought stress. [PDF]

Sci Rep
Tang Z, Wang J, Li R, Tang Y, Zhang Y, Pu G.   +5 more
europepmc   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

The Genetic Background of the Immunological and Inflammatory Aspects of Progressive Supranuclear Palsy. [PDF]

Int J Mol Sci
Alster P, Madetko-Alster N.
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Enhancer RNA transcription pinpoints functional genetic variants linked to asthma. [PDF]

Nat Commun
Sasse SK, Dahlin A, Sanford L, Gruca MA, Gupta A, Gally F, Wu AC, Iribarren C, Dowell RD, Weiss ST, Gerber AN.   +10 more
europepmc   +1 more source

The burden of burnout: Understanding its prevalence and organizational drivers in medical physics

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Burnout is a work‐related syndrome characterized by increased levels of emotional exhaustion (EE) and depersonalization (DP) along with decreased levels of personal achievement. In the healthcare setting, higher burnout levels have been associated with negative impacts on personnel, an increased risk of errors, and a decrease in the
Deborah Schofield, C. Lynn Chevalier, Laurence Court, William Harmsen, Akiva Turner   +4 more
wiley   +1 more source

Lineage-Selective Dependencies in Pediatric Cancers. [PDF]

Cold Spring Harb Perspect Med
Ritter KE, Durbin AD.
europepmc   +1 more source

LINC00323 variant is associated with increased risk of essential tremor

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Essential tremor (ET) is a common adult movement disorder, with accumulating evidence suggesting that genetic factors primarily account for ET risk. However, replication studies on the genetic variants have yielded inconsistent results. In our case–control study, we show that the LINC00323 variant, identified in a European GWAS study, is ...
Brendan Tan, Ebonne Ng, Qiao Yang Sun, Aaron Mai, Ling‐Ling Chan, Thomas Welton, Kumar M. Prakash, Kay Yaw Tay, Wing Lok Au, Louis C.S. Tan, Eng‐King Tan, Bin Xiao   +11 more
wiley   +1 more source

Harnessing neo-domestication of wild pigmented rice for enhanced nutrition and sustainable agriculture. [PDF]

Theor Appl Genet
Rathore RS, Jiang W, Sedeek K, Mahfouz M.   +3 more
europepmc   +1 more source