Results 301 to 310 of about 5,189,368 (329)
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Collinearity of Transcriptional and Traditional Genetic Maps
Nature New Biology, 1972THE transcriptional mapping method1 makes possible the detection of polycistronic operons in systems which are not amenable to fine structure genetic mapping. The theory behind transcriptional mapping is that a defined interference with the travel of the genetic transcribing enzyme can be used for genetic analysis in a variety of ways.
K S, Webb, M A, Bleyman
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Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews in Oncogenesis, 2014Raf kinase inhibitory protein (RKIP) is known to modulate key signaling cascades and regulate normal physiological processes such as cellular proliferation, differentiation, and apoptosis. The expression of RKIP is found to be downregulated in several cancer metastases and the repressed RKIP expression can be reactivated on treatment with ...
Ila, Datar +6 more
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Genetic Determinants of 5–Lipoxygenase Transcription
International Archives of Allergy and Immunology, 1999<b>Background: </b>5 Lipoxygenase (5–LO) is a critical enzyme in the production of the leukotrienes. We have identified a series of mutations in the 5–LO gene that modify gene transcription. These mutations consist of addition of an Sp–1 binding motif (–GGGCGG–) or deletion of one or two Sp–1 binding motifs in the 5–LO core promoter.
J M, Drazen, E S, Silverman
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Transcriptional derepression as a cause of genetic diseases
Current Opinion in Genetics & Development, 2003Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms.
GABELLINI D, TUPLER, Rossella, GREEN MR
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Ionizing Radiation: Effect on Genetic Transcription
Science, 1964Cells of Escherichia coli grown on maltose can be induced by the addition of thiomethyl galactoside to produce β-galactosidase. If cells are irradiated shortly after induction, the transcription of the DNA ceases, and the enzyme produced by the messenger RNA is observed to reach a maximum.
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Genetic dissection of transcriptional regulation by cDNA‐AFLP
The Plant Journal, 2006SummaryThis study demonstrates that cDNA‐AFLP is a powerful gel‐based genome‐scale transcript profiling technique to generate quantitative gene expression profiles for eQTL mapping. We used cDNA‐AFLP to monitor the relative abundance of 912 transcripts across 50 Arabidopsis thaliana recombinant inbred lines.
Marnik, Vuylsteke +4 more
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Nucleosomes and transcription: recent lessons from genetics
Current Opinion in Genetics & Development, 1997Substantial evidence exists that nucleosomes affect transcription and that additional factors modify nucleosome function. Recent work has demonstrated that different types of histone mutants can be classified by their distinct effects on transcription in vivo.
G A, Hartzog, F, Winston
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Transcription control reprogramming in genetic backup circuits
Nature Genetics, 2005A key question in molecular genetics is why severe mutations often do not result in a detectably abnormal phenotype. This robustness was partially ascribed to redundant paralogs that may provide backup for one another in case of mutation. Mining mutant viability and mRNA expression data in Saccharomyces cerevisiae, we found that backup was provided ...
Ran, Kafri +2 more
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Genetic recombination of nucleosomal templates is mediated by transcription
Molecular and General Genetics MGG, 1994An in vitro system has been developed to examine the influence of transcription on genetic rearrangement. Using a homologous pairing assay, the transfer of one strand of a nucleosomal template onto a recipient DNA molecule was monitored as a function of RNA polymerase activity.
H, Kotani +3 more
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Towards Reverse Transcription with an Expanded Genetic Alphabet
ChemBioChem, 2019AbstractUnnatural base pairs (UBPs) strikingly augment the natural genetic alphabet. The development of particular hydrophobic UBPs even allows insertion and stable propagation in bacteria. Those UBPs expand the chemical scope of DNA and RNA, and thus, could enable the evolution of novel aptamers or ribozymes by in vitro selection (systematic evolution
Frank Eggert +3 more
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