Results 291 to 300 of about 15,541,955 (379)

Disruption of intracellular processing of epidermal growth factor by methylamine inhibits epidermal growth factor-induced DNA synthesis but not early morphological or transcriptional events.

, 1987
Lynn M. Matrisian, Karin Rodland, Bruce E. Magun   +2 more
openalex   +1 more source

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Nature, 1997
J. DiDonato, M. Hayakawa, D. Rothwarf, E. Zandi, M. Karin   +4 more
semanticscholar   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq. [PDF]

Nat Genet
Liu W, Saelens W, Rainer P, Biočanin M, Gardeux V, Gralak AJ, van Mierlo G, Gebhart A, Russeil J, Liu T, Chen W, Deplancke B.   +11 more
europepmc   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Transcriptional regulation as a dose-dependent process: insights from transcription factor tuning. [PDF]

Open Biol
Noviello G.
europepmc   +1 more source

Positive and negative regulation of the gene for transcription factor IIIA in Xenopus laevis oocytes.

, 1989
Kathleen W. Scotto, Hildegard Kaulen, Robert G. Roeder   +2 more
openalex   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin

Ahel J, Mohn F, Schwaiger M, Kaaij L, Steiner J, Moreno EPF, Hess D, Bühler M.   +7 more
europepmc   +1 more source