Results 51 to 60 of about 81,203 (294)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Investigating Lexical and Syntactic Differences in Written and Spoken English Corpora

Proceedings of the International Florida Artificial Intelligence Research Society Conference
This paper presents an analysis of the differences between written text and the transcription of spoken text using current Natural Language Processing (NLP) methods.
Mina Rajaei Moghadam, Mosab Rezaei, Miguel Williams, Gülşat Aygen, Reva Freedman   +4 more
doaj   +1 more source

Seven Dimensions of Portability for Language Documentation and Description

, 2002
The process of documenting and describing the world's languages is undergoing radical transformation with the rapid uptake of new digital technologies for capture, storage, annotation and dissemination.
Bird, Steven, Simons, Gary
core   +6 more sources

Characterizing intonation deficit in motor speech disorders : an autosegmental-metrical analysis of spontaneous speech in hypokinetic dysarthria, ataxic dysarthria and foreign accent syndrome [PDF]

, 2012
The autosegmental-metrical (AM) framework represents an established methodology for intonational analysis in unimpaired speaker populations but has found little application in describing intonation in motor speech disorders (MSDs).
Kuschmann, Anja, Lowit, Anja
core   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

TEITOK, a visual solution for XML/TEI encoding: editing, annotating and hosting linguistic corpora

RIDE, 2022
TEITOK is a web-based system designed to bring scholarly editing and computational linguistics together with the purpose of creating and hosting online language corpora. The system offers a visually attractive environment for digital editing based on the
Pilar Arrabal Rodríguez
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Representing Simultaneity in Polychannel Linguistic Events: A Multitrack Method for Transcription [PDF]

Student Anthropologist, 2013
AbstractDespite the advances in audio and video recording that have been made in the last century and the implications of the more recent advent of the internet and other information sharing systems, the study of linguistic anthropology requires us from time to time to present reproductions of recorded linguistic events in a textual format — a ...
openaire   +1 more source

Polysemy and brevity versus frequency in language [PDF]

, 2019
The pioneering research of G. K. Zipf on the relationship between word frequency and other word features led to the formulation of various linguistic laws. The most popular is Zipf's law for word frequencies.
Baixeries, Jaume, Casas, Bernardino, Català, Neus, Ferrer-i-Cancho, Ramon, Hernández-Fernández, Antoni   +4 more
core   +3 more sources

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source