Results 261 to 270 of about 5,538,535 (384)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Transcription factors in Orinus: novel insights into transcription regulation for speciation adaptation on the Qinghai-Xizang (Tibet) Plateau. [PDF]

BMC Plant Biol
Min Q, Zheng K, Pang Y, Fang Y, Zhang Y, Qiao F, Su X, Chen J, Han S.   +8 more
europepmc   +1 more source

Positive and negative regulation of the gene for transcription factor IIIA in Xenopus laevis oocytes.

, 1989
Kathleen W. Scotto, Hildegard Kaulen, Robert G. Roeder   +2 more
openalex   +1 more source

Post-transcriptional regulation of ribosome formation in the nucleus of regenerating rat liver [PDF]

, 1983
K P Dudov, M D Dabeva
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Transcription regulation of African swine fever virus: dual role of M1249L. [PDF]

Nat Commun
Zhao D, Wang N, Feng X, Zhang Z, Xu K, Zheng T, Yang Y, Li X, Ou X, Zhao R, Rao Z, Bu Z, Chen Y, Wang X.   +13 more
europepmc   +1 more source

A spatially resolved stochastic model reveals the role of supercoiling in transcription regulation. [PDF]

PLoS Comput Biol, 2022
Geng Y, Bohrer CH, Yehya N, Hendrix H, Shachaf L, Liu J, Xiao J, Roberts E.   +7 more
europepmc   +1 more source

Role of transcriptional regulation and enzyme inactivation in the synthesis of Escherichia coli carbamoylphosphate synthase [PDF]

, 1980
André Pierard, Willy Lissens, Paulette Halleux, Raymond Cunin, Nicolas Glansdorff   +4 more
openalex   +1 more source

Local regulation of gene expression by lncRNA promoters, transcription and splicing

Nature, 2016
J. Engreitz, Jenna E Haines, Elizabeth M. Perez, Glen Munson, Jenny Chen, Michael Kane, P. McDonel, M. Guttman, E. Lander   +8 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source