Results 271 to 280 of about 5,538,535 (384)

Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation. [PDF]

open access: yesNat Commun
Zhou H   +12 more
europepmc   +1 more source

Regulation of heat shock transcription factors and their roles in physiology and disease

open access: yesNature reviews. Molecular cell biology, 2017
Rocío Gómez-Pastor   +2 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis. [PDF]

open access: yesNat Commun
Shi J   +15 more
europepmc   +1 more source

Transcription Regulation of Tceal7 by the Triple Complex of Mef2c, Creb1 and Myod. [PDF]

open access: yesBiology (Basel), 2022
Xiong Z   +6 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

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