Results 101 to 110 of about 8,622 (220)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1

Journal of General Virology, 2008
Since the first report of frameshifting in HCV-1, its sequence has been the paradigm for examining the mechanism that directs alternative translation of the hepatitis C virus (HCV) genome. The region encoding the core protein from this strain contains a cluster of 10 adenines at codons 8–11, which is thought to direct programmed ribosomal frameshifting
Maxime, Ratinier, Steeve, Boulant, Christophe, Combet, Paul, Targett-Adams, John, McLauchlan, Jean-Pierre, Lavergne   +5 more
openaire   +2 more sources

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, EarlyView.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source

Phenotypic Variation and Bistable Switching in Bacteria [PDF]

, 2008
Microbial research generally focuses on clonal populations. However, bacterial cells with identical genotypes frequently display different phenotypes under identical conditions.
A Becskei, A Becskei, A Guerrero, A Johnson, A Khlebnikov, A Khlebnikov, A Khlebnikov, A Lipshtat, A Moter, A Novick, AE Merode van, AE Merode van, AE Tsong, B Muller-Hill, B Slutsky, BB Magee, BE Laue, BF Brehm-Stecher, BJ Haijema, C Hadden, C Wiuff, CM Hull, CM Hull, CM Southward, CY Lan, D Angeli, D Dubnau, D Dubnau, D Dubnau, D Kidane, D Sinderen van, D Sinderen van, DB Kearns, DC Dooley, DH Dean, DR Soll, E Korobkova, E Kussell, EH Rikkerink, EJ Stewart, EM Ozbudak, EM Ozbudak, ER Sumner, EW Nester, F Jacob, F Joux, F Ortega, F Russo-Marie, FH Cahn, FH Kasten, FJ Isaacs, G Huang, G Nebe-von-Caron, GM Suel, GM Suel, H Kobayashi, H Maamar, H Makinoshima, H Steinmoen, H Steinmoen, HB Fraser, HM Davey, I Golding, I Golding, I Hautefort, IR Henderson, J Casadesus, J Hahn, J Hahn, J Hasty, J Hasty, J Holtzendorff, J Kreth, J Monod, J Vidal-Mas, J Vives-Rego, J Zieg, JD Chung, JD Chung, JD Chung, JE Ferrell Jr, JE Ferrell Jr, JE Gonzalez-Pastor, JE Lisman, JM Abraham, JM Anderson, JM Pedraza, JR Glynn Jr, JW Veening, K Lewis, KA Susanna, KP Lemon, KZ Abshire, L Cai, LF Greer III, LW Hamoen, LW Hamoen, M Acar, M Albano, M Albano, M Albano, M Cohn, M Cohn, M Lange, M Laurent, M Leisner, M Santillán, M Thattai, M Woude van der, MB Elowitz, MB Elowitz, MG Miller, MJ Hoek van, MR Barer, N Chantratita, N Friedman, N Rosenfeld, N Yildirim, N Yildirim, NC Shaner, NC Shaner, NE Kramer, NQ Balaban, P Viswanathan, PS Swain, R Amann, R Carballido-Lopez, R Thomas, R Thomas, RA Daniel, RE Zordan, RI Amann, RJ Bennett, RM Morgan-Kiss, RN Singh, RN Singh, RP Burchard, RP Haugland, RY Tsien, S Guiral, S Hooshangi, S Stibitz, SB Williams, SE Finkel, SR Biggar, SR Lockhart, SR Lockhart, SV Avery, T Hornbaek, T Nishino, T Tian, T Tolker-Nielsen, TF Meyer, TS Gardner, TT Hoa, V Sentchilo, V Sentchilo, WK Smits, WK Smits, WK Smits   +159 more
core   +3 more sources

The impact of a preprescribing formative assessment on learning in final‐year medical students using hospital inpatient electronic prescribing systems

British Journal of Clinical Pharmacology, EarlyView.
Aims Graduating medical students consistently report being unprepared for the complexity of prescribing in clinical practice. Current clinical prescribing teaching and authentic assessment are limited due to patient safety concerns. We aimed to examine the educational utility of supervised preprescribing as a learning process and potential authentic ...
Kellie A. Charles, Lorna Pairman, Emily Moon, Daniel Wong, John Quayle, Tim J. Wilkinson, Matthew Doogue, Paul Chin   +7 more
wiley   +1 more source

The expansion of amino-acid repeats is not associated to adaptive evolution in mammalian genes [PDF]

, 2009
Background The expansion of amino acid repeats is determined by a high mutation rate and can be increased or limited by selection. It has been suggested that recent expansions could be associated with the potential of adaptation to new environments.
Fernando Cruz, Julien Roux, Marc Robinson-Rechavi   +2 more
core   +2 more sources

‘Fish in simulated water’? A Bourdieusian analysis of Chinese doctoral students' learning experiences in Southeast Asian developing countries

British Educational Research Journal, EarlyView.
Abstract International student mobility (ISM) has historically followed a pattern of movement from developing regions to developed countries. However, in recent years, there has been a noticeable increase in the number of Chinese students pursuing doctoral studies in Southeast Asian developing countries, an area that has received relatively little ...
Yueyang Zheng, Kun Dai, Alan C. K. Cheung   +2 more
wiley   +1 more source

Topology of the product binding site in RNA polymerase revealed by transcript slippage at the phage lambda PL promoter.

Journal of Biological Chemistry, 1994
In the presence of transcription substrates ATP, CTP, and UTP, a stable ternary complex containing tetranucleotide AUCA is formed on the phage lambda PL promoter (starting sequence C-3A-2C-1A+1U+2C+3A+4G+5). We show that in the absence of GTP or at undersaturating GTP concentrations the AUCA transcript synthesized at the +1 to +4 segment slips back by ...
K, Severinov, A, Goldfarb
openaire   +2 more sources

Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity [PDF]

, 2014
The ExPortal protein secretion organelle in Streptococcus pyogenes is an anionic phospholipid-containing membrane microdomain enriched in Sec translocons and postsecretion protein biogenesis factors.
Caparon, Michael G., Nylander, Andrew B., Port, Gary C., Vega, Luis A.   +3 more
core   +2 more sources

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source