Results 201 to 210 of about 8,622 (220)
Protecting cell cycle integrity: enhanced start-codon stringency in mitosis. [PDF]
Signal Transduct Target TherOmrani O, Siniuk K, Fischer M.
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Journal of Molecular Biology, 1993
A C.G to A.T transversion at position +10 of the lac promoter activates a nascent sigma 70-dependent promoter (the +10A promoter). The lac +10A promoter has two unusual properties; it programs a large family of transcripts with multiple 5' ends, and its sequence bears little resemblance to other sigma 70-dependent promoters.
Ronald T Raines
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A C.G to A.T transversion at position +10 of the lac promoter activates a nascent sigma 70-dependent promoter (the +10A promoter). The lac +10A promoter has two unusual properties; it programs a large family of transcripts with multiple 5' ends, and its sequence bears little resemblance to other sigma 70-dependent promoters.
Ronald T Raines
exaly +3 more sources
Journal of Bacteriology, 2006
The Shigella flexneri transcription activator MxiE is produced by transcriptional slippage from two overlapping open reading frames. By using plasmids encoding a mxiD-lacZ translational fusion, we showed that transcriptional slippage in mxiE influences both transcription and translation of the downstream mxiD gene encoding an essential component of the
Christophe Penno
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The Shigella flexneri transcription activator MxiE is produced by transcriptional slippage from two overlapping open reading frames. By using plasmids encoding a mxiD-lacZ translational fusion, we showed that transcriptional slippage in mxiE influences both transcription and translation of the downstream mxiD gene encoding an essential component of the
Christophe Penno
exaly +2 more sources
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000
The Long-Evans Cinnamon (LEC) rat is a mutant strain characterized by abnormal copper metabolism and a high incidence of hepatitis and hepatoma. Using a yeast-based assay which scores mutants in p53 gene transcripts as red colonies, we detected frequent mutations in the liver of LEC rats.
Y, Ba +5 more
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The Long-Evans Cinnamon (LEC) rat is a mutant strain characterized by abnormal copper metabolism and a high incidence of hepatitis and hepatoma. Using a yeast-based assay which scores mutants in p53 gene transcripts as red colonies, we detected frequent mutations in the liver of LEC rats.
Y, Ba +5 more
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Transcript Slippage and Recoding
2009Accurate transmission of genetic information during transcription requires that RNA polymerases maintain the correct register of the active site during each cycle of nucleotide incorporation. The RNA:DNA hybrid plays an important role in maintaining this lateral stability, and it has been observed that when the polymerase encounters homopolymeric ...
Michael Anikin +3 more
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Reconceptualizing programmed transcriptional slippage in RNA viruses
ABSTRACTRNA viruses have evolved sophisticated strategies to exploit the limited encoded information within their typically compact genomes. One of such, named programmed transcriptional slippage (PTS), is defined by the insertion of an additional A at Anmotifs (n ≥ 6) of newly synthetized viral transcripts to get access to overlapping open reading ...Adrian A. Valli +6 more
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Molecular Microbiology, 2005
Summary Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion (TTS) system encoded by a 200 kb virulence plasmid to enter epithelial cells and trigger apoptosis in macrophages.
Christophe, Penno +2 more
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Summary Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion (TTS) system encoded by a 200 kb virulence plasmid to enter epithelial cells and trigger apoptosis in macrophages.
Christophe, Penno +2 more
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Journal of molecular biology, 2001
We have explored the effects of a variety of structural and sequence changes in the initiation region of the phage T7 promoter on promoter function. At promoters in which the template strand (T strand) is intact, initiation is directed a minimal distance of 5 nt downstream from the binding region.
Jiang, ML +3 more
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We have explored the effects of a variety of structural and sequence changes in the initiation region of the phage T7 promoter on promoter function. At promoters in which the template strand (T strand) is intact, initiation is directed a minimal distance of 5 nt downstream from the binding region.
Jiang, ML +3 more
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Biochemical and Biophysical Research Communications, 2009
Histone deacetylases (HDACs), a promising target for cancer therapy, play a role in regulating cell-cycle progression. The mechanisms for HDAC inhibition-induced regulation of G(2)/M transition and mitotic progression remain to be elucidated. Herein, we report that trichostatin A (TSA), an HDAC inhibitor, induces a delay at the G(2)/M transition ...
Noh, EL Noh, Eun Loo +3 more
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Histone deacetylases (HDACs), a promising target for cancer therapy, play a role in regulating cell-cycle progression. The mechanisms for HDAC inhibition-induced regulation of G(2)/M transition and mitotic progression remain to be elucidated. Herein, we report that trichostatin A (TSA), an HDAC inhibitor, induces a delay at the G(2)/M transition ...
Noh, EL Noh, Eun Loo +3 more
openaire +3 more sources