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Expansion Spatial Transcriptomics
Nature Methods, 2022Abstract Capture array-based spatial transcriptomics methods have been widely used to resolve gene expression in diverse tissue contexts, however, their spatial resolution is limited by array density. We present Expansion Spatial Transcriptomics (Ex-ST) to overcome this limitation by clearing and expanding tissue prior to capturing the ...
Yuhang Fan +8 more
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Interrogating the transcriptome
Trends in Biotechnology, 2004The human genome sequence and that of several model organisms have provided a remarkable view of the fundamental genetic and evolutionary templates that govern the characteristics of living organisms. Yet the real effectors of phenotype are important downstream informational elements represented first in the transcriptome and then in the proteome. This
Yijun, Ruan +3 more
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Nature Reviews Genetics, 2020
A new study in Nature Methods presents the ‘ZipSeq’ spatial transcriptomics approach, whereby patterned illumination is used to print barcodes onto chosen tissue regions.
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A new study in Nature Methods presents the ‘ZipSeq’ spatial transcriptomics approach, whereby patterned illumination is used to print barcodes onto chosen tissue regions.
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2011
Transcriptome analysis technologies are important systems-biology methods for the investigation and optimization of mammalian cell cultures concerning with regard to growth rates and productivity. For the production of recombinant proteins, knowledge of the expression conditions of the influencing genes is a major issue in the improvement of cell lines
Frank, Stahl +7 more
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Transcriptome analysis technologies are important systems-biology methods for the investigation and optimization of mammalian cell cultures concerning with regard to growth rates and productivity. For the production of recombinant proteins, knowledge of the expression conditions of the influencing genes is a major issue in the improvement of cell lines
Frank, Stahl +7 more
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Transcriptomic Analyses of Phytoplasmas
2018Transcriptomic analyses addressed to study phytoplasma gene expression may present few difficulties due to the uncultivable nature of these intracellular, obligate pathogens. While RNA extraction from insect vectors does not imply any particular adaptation of the protocols used in most commercial kits, RNA isolation from phytoplasma-infected plants can
Pacifico D, Abba S, Palmano S
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2017
This chapter focuses on transcriptomes. A transcriptome is the inventory of the RNA molecules in a cell. The chapter differentiates between proteomes and genomes. It explains the relationship between microarray technology and RNAseq methods, including the gene expression table and how it is derived from experiments using these methods. It clarifies the
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This chapter focuses on transcriptomes. A transcriptome is the inventory of the RNA molecules in a cell. The chapter differentiates between proteomes and genomes. It explains the relationship between microarray technology and RNAseq methods, including the gene expression table and how it is derived from experiments using these methods. It clarifies the
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Distinct Transcriptome Architectures Underlying Lupus Establishment and Exacerbation
Cell, 2022Masahiro Nakano +2 more
exaly
Single-Cell Spatial Transcriptome Reveals Cell-Type Organization in the Macaque Cortex
Cell, 2023Wu Wei, Chengyu T Li, Xing Sun
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Whole-Genome and Transcriptome Analysis Enhances Precision Cancer Treatment Options
Annals of Oncology, 2022A Tinker, E Pleasance, K J Savage
exaly
Single-Cell Transcriptome Analysis in Plants: Advances and Challenges
Molecular Plant, 2021Xu J Jian, Rahul Shaw, Xin Tian
exaly