Results 251 to 260 of about 602,244 (307)

Interpretable spatial multi-omics data integration and dimensionality reduction with SpaMV. [PDF]

Nat Commun
Liu Y, Ma K, Xu H, Xu K, Hu Y, Lin Z, Lin J, Han B, Li S, Lin Z, Zhou XM, Zhang L.   +11 more
europepmc   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Antennal Transcriptome Profiling Reveals Gustatory Receptors Associated with Pollen Foraging Preferences in <i>Apis mellifera</i>. [PDF]

Animals (Basel)
Su Q, Zhang Y, Song C, Guo L, Guo Y.
europepmc   +1 more source

Placental transcriptome profiling and immune signature differences in pregnancies with and without gestational diabetes mellitus: An observational study: Erratum. [PDF]

Medicine (Baltimore)
Kang YE, Lee SE, Lim JY, Kim OS, Yoon J, Jung Y, Lee JH, Ku BJ, Lee M, Kim HJ.   +9 more
europepmc   +1 more source

Integrated Transcriptomic and Metabolomic Analyses Uncover the Molecular Mechanisms Underlying Drought Tolerance in <i>Isodon suzhouensis</i>. [PDF]

Genes (Basel)
Liu F, Pan L.
europepmc   +1 more source

Metabolomics and Transcriptomics Studies of the Differential Accumulation of Flavonoids in Different Organs in <i>Emilia sonchifolia</i>. [PDF]

Int J Mol Sci
Jiang X, Wei R, Qin Y, Yao J, Cai W, Huang M, Sooranna S, Huang Y, Liang L, Wang J, Tan L, Liang C, Wang L, Yang S, Tu D.   +14 more
europepmc   +1 more source

Breed-specific meat quality and flavor characteristics of Wannan and Chinese Simmental cattle revealed by whole transcriptome and metabolome analysis. [PDF]

Food Chem (Oxf)
Song N, Wang J, Meng X, Cui S, Jin S, Tang H, Zhang Y, Liu H.   +7 more
europepmc   +1 more source